N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid

Base Information

• Chemical Name: N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid
• CAS No.: 96846-11-6
• Molecular Formula: C₂₀H₂₄N₁₀O₄
• Molecular Weight: 468.475

Synonyms:N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid

Chemical Property of N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid

There total 5 articles about N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

6-bromomethyl-2,4-diaminopteridine hydrobromide (52853-40-4) + N2-<4-(methylamino)benzoyl>-2-amino-3-<<(methylamino)carbonyl>amino>propanoic acid (96846-08-1) → N-2-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid (96846-11-6)

Guidance literature:

In N,N-dimethyl acetamide; at 20 - 25 ℃; for 120h;

DOI:10.1021/jm00146a008

Reference yield:

benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate (66891-86-9) → N-2-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid (96846-11-6)

Guidance literature:

Multi-step reaction with 3 steps

1: (i-Pr)2NEt / dioxane; H₂O

2: H₂ / 30percent Pd/C / acetic acid / 3.5 h / 25 °C / 2324.2 Torr

3: 50 percent / N,N-dimethyl-acetamide / 120 h / 20 - 25 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; acetic acid;

DOI:10.1021/jm00146a008

Reference yield:

N2-<(4-methylphenyl)sulfonyl>-2-amino-3-<<(methylamino)carbonyl>amino>propanoic acid (96846-01-4) → N-2-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid (96846-11-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 30percent HBr, CH₃COOH, phenol / 96 h

2: (i-Pr)2NEt / dioxane; H₂O

3: H₂ / 30percent Pd/C / acetic acid / 3.5 h / 25 °C / 2324.2 Torr

4: 50 percent / N,N-dimethyl-acetamide / 120 h / 20 - 25 °C

With hydrogen bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; phenol; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl acetamide; water; acetic acid;

DOI:10.1021/jm00146a008

upstream raw materials:

6-bromomethyl-2,4-diaminopteridine hydrobromide

N²-<4-(methylamino)benzoyl>-2-amino-3-<<(methylamino)carbonyl>amino>propanoic acid

benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate

N²-<(4-methylphenyl)sulfonyl>-2-amino-3-<<(methylamino)carbonyl>amino>propanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 96846-11-6 N-²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-3-<<(methylamino)carbonyl>amino>propanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send