4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

Base Information

Chemical Name:4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI
CAS No.:1451055-87-0
Molecular Formula:C₃₉H₅₀O₁₂
Molecular Weight:710.819
Hs Code.:

Synonyms:4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

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Chemical Property of 4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

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Technology Process of 4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

There total 6 articles about 4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1451055-96-1
4-deacetyl-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1451055-87-0
4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

Guidance literature:: 4-deacetyl-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃;

cyclopropanecarboxylic acid chloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1007/s00706-013-0981-z

Reference yield:

: 939961-10-1
4,7,9,10,13-pentadeacetyl-9,10-O-isopropylidene-1-deoxybaccatin VI

: 1451055-87-0
4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-benzyl-trimethylammonium hydroxide / 20 °C

2.1: dmap / tetrahydrofuran / 0 °C

3.1: dmap; dicyclohexyl-carbodiimide / toluene / 6 h / 50 °C

4.1: dmap; dicyclohexyl-carbodiimide / toluene / 5 h / Heating

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

5.2: 0 °C

With dmap; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1007/s00706-013-0981-z

Reference yield:

: 4,7,9,10,13-pentadeacetyl-1-dehydroxybaccatin VI

: 1451055-87-0
4-(cyclopropanecarbonyl)-9,10-O-isopropylidene-2-(3-methoxybenzoyl)-1-deoxybaccatin VI

Guidance literature:: Multi-step reaction with 6 steps

1.1: Montmorillonite K₁₀ / 20 °C

2.1: N-benzyl-trimethylammonium hydroxide / 20 °C

3.1: dmap / tetrahydrofuran / 0 °C

4.1: dmap; dicyclohexyl-carbodiimide / toluene / 6 h / 50 °C

5.1: dmap; dicyclohexyl-carbodiimide / toluene / 5 h / Heating

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

6.2: 0 °C

With dmap; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1007/s00706-013-0981-z