3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

Base Information

Chemical Name:3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine
CAS No.:1416000-33-3
Molecular Formula:C₂₅H₁₄F₃N₅O
Molecular Weight:457.414
Hs Code.:

Synonyms:3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

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Chemical Property of 3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

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Technology Process of 3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

There total 11 articles about 3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.6%

: 1416000-57-1
2-chloro-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5]naphthyridin-9(10H)-one

: 1150561-70-8
3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine

: 1416000-33-3
3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;

Reference yield:

: 1416000-54-8
6-chloro-4-((3-(trifluoromethyl)phenyl)amino)-1,5-naphthyridine-3-carbaldehyde

: 1416000-33-3
3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / N,N-dimethyl acetamide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic anhydride; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 3430-18-0,141315-43-7
2,5-dibromo-3-methylpyridine

: 1416000-33-3
3-methyl-5-(9-oxo-10-(3-(trifluoromethyl) phenyl)-9,10-dihydropyrido[3,2-c][1,5] naphthyridin-2-yl)-2-cyanopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: water; N,N-dimethyl-formamide

2: potassium acetate

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In dichloromethane; water; N,N-dimethyl-formamide;