2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

Base Information

Chemical Name:2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid
CAS No.:1491169-48-2
Molecular Formula:C₂₂H₁₅F₇N₂O₂
Molecular Weight:472.362
Hs Code.:

Synonyms:2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

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Chemical Property of 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

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Technology Process of 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

There total 7 articles about 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1491169-19-7
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester

: 1491169-48-2
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 1491168-99-0
ethyl 4-(2-fluorophenyl)nicotinate

: 1491169-48-2
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

3.1: triphenylphosphine / water; tetrahydrofuran / 20 °C

4.1: hydrogenchloride

5.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

5.2: 3 h / 0 - 20 °C / Inert atmosphere

6.1: sodium hydroxide / methanol / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; 3.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1491169-48-2
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 12 h / 85 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

4.1: triphenylphosphine / water; tetrahydrofuran / 20 °C

5.1: hydrogenchloride

6.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

6.2: 3 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hydroxide / methanol / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile; 1.1: |Suzuki Coupling / 4.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050