2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester

Base Information

• Chemical Name: 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester
• CAS No.: 1491169-19-7
• Molecular Formula: C₂₃H₁₇F₇N₂O₂
• Molecular Weight: 486.389
• Mol file: 1491169-19-7.mol

Synonyms:2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester

Chemical Property of 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester

There total 16 articles about 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(4-(2-fluorophenyl)pyridin-3-yl)methanamine dihydrochloride + 2-(3,5-bis(trifluoromethyl)phenyl)-2-bromoacetic acid methyl ester (151954-43-7) → 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester (1491169-19-7)

Guidance literature:

2-(3,5-bis(trifluoromethyl)phenyl)-2-bromoacetic acid methyl ester; With triethylamine; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

(4-(2-fluorophenyl)pyridin-3-yl)methanamine dihydrochloride; In acetonitrile; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/cmdc.201300144

Reference yield: 35.0%

(4-(2-fluorophenyl)pyridin-3-yl)methanamine hydrochloride + 2-(3,5-bis(trifluoromethyl)phenyl)-2-bromoacetic acid methyl ester (151954-43-7) → 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester (1491169-19-7)

Guidance literature:

2-(3,5-bis(trifluoromethyl)phenyl)-2-bromoacetic acid methyl ester; With triethylamine; In acetonitrile; for 0.5h; Cooling with ice; Inert atmosphere;

(4-(2-fluorophenyl)pyridin-3-yl)methanamine hydrochloride; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

2-chloro-4-(2-fluorophenyl)nicotinic acid ethyl ester (1491169-11-9) → 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid methyl ester (1491169-19-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 0 °C / Reflux

3.1: triphenylphosphine; water / tetrahydrofuran / 20 °C

4.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 3 h / 20 °C

5.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

5.2: 3 h / 0 - 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; 3.1: |Staudinger Azide Reduction;

DOI:10.1002/cmdc.201300144

upstream raw materials:

2-chloro-4-(2-fluorophenyl)nicotinic acid ethyl ester

(2-chloro-4-(2-fluorophenyl)pyridin-3-yl)methanol

3-(azidomethyl)-2-chloro-4-(2-fluorophenyl)pyridine

2-(3,5-bis(trifluoromethyl)phenyl)-2-bromoacetic acid methyl ester

Downstream raw materials:

2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetic acid