diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

Base Information

Chemical Name:diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate
CAS No.:1383545-77-4
Molecular Formula:C₂₄H₂₃ClO₅
Molecular Weight:426.897
Hs Code.:

Synonyms:diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

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Chemical Property of diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

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Technology Process of diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

There total 4 articles about diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₁ClO₅

: 1774-47-6
trimethylsulfoxonium iodide

: 1383545-77-4
diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; at 0 - 50 ℃; for 3h; Inert atmosphere;
DOI:10.1002/asia.201200104

Reference yield:

: 1224712-72-4
5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)benzaldehyde

: 1383545-77-4
diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / chloroform / Reflux

2: sodium hydride / dimethyl sulfoxide / 3 h / 0 - 50 °C / Inert atmosphere

With piperidine; sodium hydride; In chloroform; dimethyl sulfoxide;
DOI:10.1002/asia.201200104

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 1383545-77-4
diethyl 2-(5-chloro-2-((3-phenylprop-2-yn-1-yl)oxy)phenyl)cyclopropane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere

3: piperidine / chloroform / Reflux

4: sodium hydride / dimethyl sulfoxide / 3 h / 0 - 50 °C / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/asia.201200104