(S)-α-cyano-α-fluoro-p-tolylacetyl chloride

Base Information

Chemical Name:(S)-α-cyano-α-fluoro-p-tolylacetyl chloride
CAS No.:677300-31-1
Molecular Formula:C₁₀H₇ClFNO
Molecular Weight:211.623
Hs Code.:

Synonyms:(S)-α-cyano-α-fluoro-p-tolylacetyl chloride

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Chemical Property of (S)-α-cyano-α-fluoro-p-tolylacetyl chloride

Chemical Property:

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Technology Process of (S)-α-cyano-α-fluoro-p-tolylacetyl chloride

There total 6 articles about (S)-α-cyano-α-fluoro-p-tolylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 204119-08-4
(S)-α-cyano-α-fluoro-p-tolylacetic acid

: 677300-31-1
(S)-α-cyano-α-fluoro-p-tolylacetyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2003.12.024

Reference yield:

: 204119-06-2
ethyl α-cyano-α-fluoro-p-tolylacetate

: 677300-31-1
(S)-α-cyano-α-fluoro-p-tolylacetyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 731 mg / LiOH / tetrahydrofuran; H₂O / 0.33 h / 20 °C

2: 519 mg / (COCl)2; DMF / CH₂Cl₂ / 3 h / 20 °C

3: 44 percent / pyridine / CH₂Cl₂ / 5 h / 20 °C

4: 87 percent / LiOH / tetrahydrofuran; H₂O / 0.08 h / 20 °C

5: (COCl)2; DMF / CH₂Cl₂ / 20 °C

With pyridine; lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol0479489

Reference yield:

: 2947-61-7
(4-methylphenyl)acetonitrile

: 677300-31-1
(S)-α-cyano-α-fluoro-p-tolylacetyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / NaH / tetrahydrofuran / 2 h / Heating

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 95 percent / FClO₃ / tetrahydrofuran / 2 h / 20 °C

3.1: 731 mg / LiOH / tetrahydrofuran; H₂O / 0.33 h / 20 °C

4.1: 519 mg / (COCl)2; DMF / CH₂Cl₂ / 3 h / 20 °C

5.1: 44 percent / pyridine / CH₂Cl₂ / 5 h / 20 °C

6.1: 87 percent / LiOH / tetrahydrofuran; H₂O / 0.08 h / 20 °C

7.1: (COCl)2; DMF / CH₂Cl₂ / 20 °C

With pyridine; lithium hydroxide; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol0479489