204119-06-2

Upstream product

• 147795-55-9 ethyl 2-cyano-2-(p-tolyl)acetate 
• 2947-61-7 (4-methylphenyl)acetonitrile 

Downstream Products

• 253178-32-4 (+/-)-α-cyano-α-fluoro-p-tolylacetic acid 
• 677300-27-5 (S)-Cyano-fluoro-p-tolyl-acetic acid (1R,2S)-1-benzyloxycarbonylamino-indan-2-yl ester 
• 809286-03-1 (S)-α-cyano-α-fluoro-p-tolylacetic acid (1R,3R,4R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl ester 
• 809286-04-2 (R)-α-cyano-α-fluoro-p-tolylacetic acid (1R,3R,4R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl ester 

Relevant academic research and scientific papers

A very reliable method for determination of absolute configuration of chiral secondary alcohols by 1H NMR spectroscopy

(Chemical equation presented) Surprisingly stable synperiplanar conformers of CFTA esters have led us to develop a new and very reliable method for assigning absolute configurations of even secondary alcohols having minimal structural differences, such as chiral benzhydrols and α-monodeuterated benzyl alcohols.

Efficient synthesis of a new, highly versatile chiral derivatizing agent, α-cyano-α-fluoro-p-tolylacetic acid (CFTA)

The new and versatile chiral derivatizing agent, α-cyano-α-fluoro-p-tolylacetic acid (CFTA), has been efficiently synthesized in optically pure form by Candida rugosa lipase-mediated kinetic resolution of racemic CFTA ethyl ester, the latter being readily