4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

Base Information

Chemical Name:4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran
CAS No.:526197-97-7
Molecular Formula:C₁₉H₂₆O₃
Molecular Weight:302.414
Hs Code.:

Synonyms:4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

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Chemical Property of 4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

Chemical Property:

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Technology Process of 4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

There total 7 articles about 4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

: 866129-80-8
4-tert-butyl-5-[3-(carboxymethyl)phenyl]-3,3-dimethyl-2,3-dihydrofuran

: 74-88-4
methyl iodide

: 526197-97-7
4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tet.2005.07.081

Reference yield:

: 866129-75-1
5-[3-(bromomethyl)phenyl]-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

: 526197-97-7
4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 76.4 percent / tetra-n-butylammonium hydrogen sulfate / tetrahydrofuran; H₂O / 28 h / Heating

2: 97.4 percent / NaOH / ethanol; H₂O / 2 h / Heating

3: 89.7 percent / NaHCO₃ / dimethylformamide / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.07.081

Reference yield:

: 526197-85-3
4-tert-butyl-5-[3-(cyanomethyl)phenyl]-3,3-dimethyl-2,3-dihydrofuran

: 526197-97-7
4-tert-butyl-5-[3-(methoxycarbonylmethyl)-phenyl]-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 97.4 percent / NaOH / ethanol; H₂O / 2 h / Heating

2: 89.7 percent / NaHCO₃ / dimethylformamide / 20 °C

With sodium hydroxide; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.07.081