Technology Process of 7-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-1,3,4-thiadiazolo<3,2-a>pyrimidin-5-one
There total 6 articles about 7-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-1,3,4-thiadiazolo<3,2-a>pyrimidin-5-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tri-n-propylamine; trichlorophosphate;
at 80 - 85 ℃;
for 3h;
DOI:10.1248/cpb.40.2391
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94.1 percent / H2 / 5percent Pd/C / ethanol / 760 Torr
2: 83 percent / CF3COOH
3: 81.7 percent / heptane / 2 h / 140 - 150 °C
4: 91.2 percent / fuming HNO3, AcOH / 2.5 h / Ambient temperature
5: 96.3 percent / tripropylamine, POCl3 / 3 h / 80 - 85 °C
With
tri-n-propylamine; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; n-heptane;
DOI:10.1248/cpb.40.2391
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94.1 percent / 40percent aq. NaOH / CH2Cl2 / 2 h / Ambient temperature
2: 94.1 percent / H2 / 5percent Pd/C / ethanol / 760 Torr
3: 83 percent / CF3COOH
4: 81.7 percent / heptane / 2 h / 140 - 150 °C
5: 91.2 percent / fuming HNO3, AcOH / 2.5 h / Ambient temperature
6: 96.3 percent / tripropylamine, POCl3 / 3 h / 80 - 85 °C
With
tri-n-propylamine; sodium hydroxide; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; trichlorophosphate;
palladium on activated charcoal;
In
ethanol; n-heptane; dichloromethane;
DOI:10.1248/cpb.40.2391
