ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

Base Information

Chemical Name:ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate
CAS No.:1598420-68-8
Molecular Formula:C₂₄H₃₅BrN₂O₆
Molecular Weight:527.456
Hs Code.:

Synonyms:ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

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Chemical Property of ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

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Technology Process of ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

There total 4 articles about ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 72707-66-5
2-(bromomethyl)acrylic acid

: 1212264-50-0
(S)-α-(2,4-dimethoxyphenyl)ethylamine

: 590-86-3
isovaleraldehyde

: 1598420-68-8
ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

: 1598420-58-6
ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

Guidance literature:: (S)-α-(2,4-dimethoxyphenyl)ethylamine; isovaleraldehyde; In ethanol; at 20 ℃; for 0.5h;

Ethyl isocyanoacetate; 2-(bromomethyl)acrylic acid; In ethanol; at 0 - 20 ℃; Overall yield = 84 %;
DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

: 829-20-9
2',4'-dimethoxyacetophenone

: 1598420-68-8
ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium carbonate / water / 2 h / 135 °C / Reflux

1.2: Reflux

2.1: sodium hydroxide / water / 4 h / Reflux

3.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

4.1: ethanol / 0.5 h / 20 °C

4.2: 0 - 20 °C

With ammonium carbonate; sodium hydroxide; In ethanol; water; toluene; 4.1: |Ugi Condensation / 4.2: |Ugi Condensation;
DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

: C₁₆H₁₇NO₃

: 1598420-68-8
ethyl 2-[2-{2-(bromomethyl)-N-(1-{2,4-dimethoxyphenyl}ethyl)acrylamido}-4-methylpentanamido]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 4 h / Reflux

2.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

3.1: ethanol / 0.5 h / 20 °C

3.2: 0 - 20 °C

With sodium hydroxide; In ethanol; water; toluene; 3.1: |Ugi Condensation / 3.2: |Ugi Condensation;
DOI:10.1016/j.tetasy.2014.01.016