N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Base Information

Chemical Name:N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide
CAS No.:209798-67-4
Molecular Formula:C₁₇H₁₉F₂N₃O₄
Molecular Weight:367.352
Hs Code.:

Synonyms:N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Suppliers and Price of N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

There total 5 articles about N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 209798-63-0
7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-phenyl-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione

: 209798-67-4
N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Guidance literature:: With hydrogenchloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4020(98)00329-9

Reference yield:

: 907958-40-1
N,N-dimethyl-3-(1,3-dimethyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

: 209798-67-4
N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Guidance literature:: With hydrogenchloride; at 20 ℃;
DOI:10.1016/S0040-4020(98)00329-9

Reference yield:

: 769-42-6
1,3-dimethylbarbituric acid

: 209798-67-4
N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / aq. ethanol / Heating

2: 87 percent / hexane; dimethylformamide / 0.17 h / 20 °C

3: 84 percent / conc. HCl / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: hetero-Diels-Alder reaction / 3: Hydrolysis;
DOI:10.1016/S0040-4020(98)00329-9