4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

Base Information

Chemical Name:4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid
CAS No.:173457-20-0
Molecular Formula:C₃₀H₃₃ClN₂O₉S₃
Molecular Weight:697.251
Hs Code.:

Synonyms:4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

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Chemical Property of 4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

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Technology Process of 4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

There total 6 articles about 4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173457-19-7
4-{4-Chloro-3-[2-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-acetylsulfamoyl]-benzoylsulfamoyl}-benzoic acid ethyl ester

: 173457-20-0
4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 20h;
DOI:10.1021/jm960772z

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 173457-20-0
4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / K₂CO₃

2: 46 percent / TFA / CH₂Cl₂

3: DMAP, DCC / dimethylformamide / 48 h / Ambient temperature

4: aq. NaOH / ethanol / 20 h / 60 °C

5: DCC, DMAP / dimethylformamide / 2 h / Ambient temperature

6: aq. NaOH / ethanol / 20 h / 60 °C

With dmap; sodium hydroxide; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960772z

Reference yield:

: 61151-53-9
4-hydroxy-3,5-di-tert-butylphenylmercaptoacetic acid

: 173457-20-0
4-{[({4-chloro-3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]phenyl}carbonyl)amino]sulfonyl}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP, DCC / dimethylformamide / 48 h / Ambient temperature

2: aq. NaOH / ethanol / 20 h / 60 °C

3: DCC, DMAP / dimethylformamide / 2 h / Ambient temperature

4: aq. NaOH / ethanol / 20 h / 60 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960772z