4-chloro-6-fluoroindoline-2,3-dione

Base Information

• Chemical Name: 4-chloro-6-fluoroindoline-2,3-dione
• CAS No.: 940054-45-5
• Molecular Formula: C₈H₃ClFNO₂
• Molecular Weight: 199.569
• Hs Code.: 2933998090
• Mol file: 940054-45-5.mol

Synonyms:4-chloro-6-fluoro-1H-indole-2,3-dione

Chemical Property of 4-chloro-6-fluoroindoline-2,3-dione

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-chloro-6-fluoro-2,3-dihydro-1H-indole-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-6-fluoroindoline-2,3-dione

There total 4 articles about 4-chloro-6-fluoroindoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-chloro-5-fluorophenyl)-2-hydroxyimino-acetamide (940054-44-4) → 4-chloro-6-fluoro-1H-indole-2,3-dione (940054-45-5) + 6-chloro-4-fluoro-1H-indole-2,3-dione (940054-46-6)

Guidance literature:

N-(3-chloro-5-fluorophenyl)-2-hydroxyimino-acetamide; With sulfuric acid; at 50 - 100 ℃; for 0.75h;

With water;

Reference yield:

3-chloro-5-fluoro-benzoic acid (25026-64-6) → 4-chloro-6-fluoro-1H-indole-2,3-dione (940054-45-5)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 16 h / Heating / reflux

2: hydrogenchloride / 1,4-dioxane; methanol / 20 h / 20 °C

3: hydroxylamine hydrochloride; sodium sulfate / water / 16.67 h / 20 °C / Heating / reflux

4: sulfuric acid / 0.75 h / 50 - 100 °C

With hydrogenchloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium sulfate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water; toluene;

Reference yield:

(3-chloro-5-fluorophenyl)-carbamic acid tert-butyl ester (940054-42-2) → 4-chloro-6-fluoro-1H-indole-2,3-dione (940054-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 20 h / 20 °C

2: hydroxylamine hydrochloride; sodium sulfate / water / 16.67 h / 20 °C / Heating / reflux

3: sulfuric acid / 0.75 h / 50 - 100 °C

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In 1,4-dioxane; methanol; water;

upstream raw materials:

N-(3-chloro-5-fluorophenyl)-2-hydroxyimino-acetamide

3-chloro-5-fluoro-benzoic acid

(3-chloro-5-fluorophenyl)-carbamic acid tert-butyl ester

3-chloro-5-fluoroaniline hydrochloride

Downstream raw materials:

2-amino-6-chloro-4-fluoro-benzoic acid

2-amino-4-chloro-6-fluorobenzoic acid

Refernces