cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

Base Information

Chemical Name:cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)
CAS No.:782492-21-1
Molecular Formula:C₃₃H₃₈F₃N₃O₆S
Molecular Weight:661.742
Hs Code.:

cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

Synonyms:cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

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Chemical Property of cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

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Technology Process of cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

There total 6 articles about cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 782493-17-8
(3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentanone

: 782493-39-4
5-piperidin-4-ylisoxazol-3-yl 4-methylbenzenesulfonate hydrochloride

: 782492-21-1
cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

: trans (5-[1-((1S,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; at 20 ℃; for 144h;

Reference yield:

: 782493-22-5
(3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentanol

: 782492-21-1
cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

: trans (5-[1-((1S,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C

1.2: 1.67 h / -78 - 20 °C

2.1: sodium tris(acetoxy)borohydride; triethylamine / 144 h / 20 °C / Molecular sieve

With oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; In dichloromethane;

Reference yield:

: 782493-42-9
tert-butyl 4-(3-hydroxyisoxazol-5-yl)piperidine-1-carboxylate

: 782492-21-1
cis (5-[1-((1R,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

: trans (5-[1-((1S,3S)-3-isopropyl-3-{[6-(trifluoromethyl)-2H-1,3-benzoxazin-3(4H)-yl]carbonyl}cyclopentyl)piperidin-4-yl]isoxazol-3-yl 4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: sodium tris(acetoxy)borohydride; triethylamine / 144 h / 20 °C / Molecular sieve

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; 1,4-dioxane;