4-{[(4-Methylphenyl)amino]methyl}phenol

Base Information

Chemical Name:4-{[(4-Methylphenyl)amino]methyl}phenol
CAS No.:107455-66-3
Molecular Formula:C₁₄H₁₅NO
Molecular Weight:213.279
Hs Code.:
European Community (EC) Number:665-426-7
DSSTox Substance ID:DTXSID60394634
Wikidata:Q82194143
Mol file:107455-66-3.mol

Synonyms:4-{[(4-methylphenyl)amino]methyl}phenol;107455-66-3;4-[(4-methylanilino)methyl]phenol;4-((p-Tolylamino)methyl)phenol;4-([(4-Methylphenyl)amino]methyl)phenol;4-(4-toluidinomethyl)phenol;SCHEMBL6555950;DTXSID60394634;MFCD00029721;STK802645;AKOS000112145;SB79431;NCGC00339179-01;LS-03958;AB01331336-02

Suppliers and Price of 4-{[(4-Methylphenyl)amino]methyl}phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-{[(4-Methylphenyl)amino]methyl}phenol
100mg
$ 155.00

TRC
4-{[(4-Methylphenyl)amino]methyl}phenol
10mg
$ 45.00

Sigma-Aldrich
ALPHA-(P-TOLUIDINO)-P-CRESOL Aldrich
250mg
$ 33.40

Matrix Scientific
4-{[(4-Methylphenyl)amino]methyl}phenol
500mg
$ 237.00

Crysdot
4-((p-Tolylamino)methyl)phenol 95+%
5g
$ 752.00

AK Scientific
4-{[(4-Methylphenyl)amino]methyl}phenol
500mg
$ 369.00

Total 3 raw suppliers

Chemical Property of 4-{[(4-Methylphenyl)amino]methyl}phenol

Chemical Property:

Melting Point:90 °C(Solv: ligroine (8032-32-4); benzene (71-43-2))
Boiling Point:379.9±22.0 °C(Predicted)
PKA:9.66±0.15(Predicted)
Density:1.157±0.06 g/cm3(Predicted)
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:213.115364102
Heavy Atom Count:16
Complexity:191

Purity/Quality:

98%min ^*data from raw suppliers

4-{[(4-Methylphenyl)amino]methyl}phenol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)NCC2=CC=C(C=C2)O

Technology Process of 4-{[(4-Methylphenyl)amino]methyl}phenol

There total 8 articles about 4-{[(4-Methylphenyl)amino]methyl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107917-24-8
4-(N-Nitroso-p-toluidinomethyl)-phenol

: 107455-66-3
4-((p-tolylamino)methyl)phenol

Guidance literature:: With triethylsilane; iodine; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1002/adsc.201701047

Reference yield:

: 2101-86-2
p-methylazidobenzene

: 6554-98-9
trans-4-Hydroxystilbene

: 5405-15-2
N-benzyl-N-(4-methylphenyl)amine

: 107455-66-3
4-((p-tolylamino)methyl)phenol

Guidance literature:: p-methylazidobenzene; trans-4-Hydroxystilbene; With iron(II) chloride; In acetonitrile; at 100 ℃; for 9h; Sealed tube; Inert atmosphere;

With methanol; sodium tetrahydroborate; at 20 ℃;
DOI:10.1021/acs.orglett.9b03160

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 5405-15-2
N-benzyl-N-(4-methylphenyl)amine

: 107455-66-3
4-((p-tolylamino)methyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 10 h / 20 °C / Inert atmosphere

2.1: iron(II) chloride / acetonitrile / 9 h / 100 °C / Sealed tube; Inert atmosphere

2.2: 20 °C

With hydrogenchloride; iron(II) chloride; sodium nitrite; In water; acetonitrile;
DOI:10.1021/acs.orglett.9b03160