2101-86-2

Basic information

• Product Name: NISTC2101862
• Synonyms: NISTC2101862;1-Methyl-4-azidobenzene;4-Azidotoluene;4-Methyl-1-azidobenzene;4-Methylphenyl azide;p-Methylphenyl azide;4-Azidotoluene solution;4-Azidotoluene solution ~0.5 M in tert-butyl methyl ether, >=95.0% (HPLC)
• CAS NO: 2101-86-2
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.1506
• Mol File: 2101-86-2.mol
• Article Data: 159

Chemical Properties

• Melting Point: -29°C
• Boiling Point: 235.67°C (rough estimate)
• Flash Point: -33℃
• Appearance: /
• Density: 1.0527
• Refractive Index: 1.5341 (estimate)
• Storage Temp.: ?20°C
• BRN: 1841411
• CAS DataBase Reference: NISTC2101862(CAS DataBase Reference)
• NIST Chemistry Reference: NISTC2101862(2101-86-2)
• EPA Substance Registry System: NISTC2101862(2101-86-2)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-38
• Safety Statements: 16
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 2101-86-2(Hazardous Substances Data)

Usage

Uses

4-Azidotoluene solution may be used for the functionalization at the axial position of boron subphthalocyanines with a terminal acetylene functionality via copper(I)-catalyzed azide-alkyne cycloaddition in the presence of Hunig′s base.

General Description

4-Azidotoluene is an aromatic azide generally used in copper(I)-catalyzed azide-alkyne cycloaddition reactions.

InChI:InChI=1/C7H7N3/c1-6-2-4-7(5-3-6)9-10-8/h2-5H,1H3

Upstream product

• 539-44-6 N-4-methylphenylhydrazine 
• 14106-51-5 p-tolyl-diazenecarboxylic acid amide 
• 3144-09-0 methanesulfonamide 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 7334-78-3 p-CH₃C₆H₄NNN(NH₂)C₆H₅ 
• 7664-93-9 sulfuric acid 
• 67-56-1 methanol 
• 32785-43-6 p-tolyl-pentazole 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 403615-38-3 2-azido-1,3-diiodo-5-methyl-benzene 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 108-88-3 toluene 
• 540-23-8 p-toluidine hydrochloride 

Downstream Products

• 20667-76-9 1-methyl-3-(p-tolyl)triaz-1-ene 
• 108840-87-5 4-phenyl-1-(p-tolyl)-1H-1,2,3-triazol-5-amine 
• 72680-08-1 ethyl 5-amino-1-p-tolyl-1H-1,2,3-triazole-4-carboxylate 
• 2327-67-5 N-(p-tolyl)-P,P,P-triphenylphosphine imide 
• 66172-26-7 2-p-tolyl-5-(2,2,2-trifluoro-1-trifluoromethyl-ethylidene)-2,5-dihydro-[1,2,3,4]thiatriazole 
• 20113-27-3 tributyl-N-(p-tolyl)-phosphorimidate 
• 19946-86-2 C₁₅H₂₇ClN₃P 
• 93-58-3 benzoic acid methyl ester 
• 3085-54-9 N-(4-methylphenyl)formamide 
• 106-49-0 p-toluidine 
• 90861-95-3 4-methyl-2-tetrahydro-2-thienylaniline 
• 128957-47-1 1-(3-p-Tolyl-3H-[1,2,3]triazol-4-yl)-piperidine 
• 128957-44-8 4-(3-p-Tolyl-3H-[1,2,3]triazol-4-yl)-morpholine 
• 128654-37-5 9-(p-tolyl)-9-azabicyclo<6.1.0>nonane 

Relevant articles and documents

Cu(i)-catalyzed microwave-assisted synthesis of 1,2,3-triazole linked with 4-thiazolidinones: A one-pot sequential approach

A novel copper(i) catalyzed, microwave-assisted one-pot, four-component sequential reaction between a propargyloxybenzaldehyde, a substituted phenyl azide, a substituted aniline and thioglycolic acid has been developed for the synthesis of 3-phenyl-2-[4-{

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A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates

It has recently emerged that the succinimide linkage of a maleimide thiol addition product is fragile, which is a major issue in fields where thiol functionalisation needs to be robust. Herein we deliver a strategy that generates selective cysteine thiol

Triazole [5, 4-d] pyrimidone tricyclic compounds as well as preparation method and application thereof

The invention relates to triazole [5, 4-d] pyrimidone tricyclic compounds as well as a preparation method and application thereof.The triazole [5, 4-d] pyrimidone tricyclic compounds are prepared by following steps: taking different substituted anilines a

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents

The benzothiazinone (BTZ) scaffold compound PBTZ169 kills Mycobacterium tuberculosis by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall component arabinans. While extraordinarily potent against M. tuberculosis with a minimum inhibitory concentration (MIC) less than 0.2 ng/mL, its low aqueous solubility and bioavailability issues need to be addressed. Here, we designed and synthesized a series of 6-methanesulfonyl substituted BTZ analogues; further exploration introduced five-member aromatic heterocycles as linkers to attach an aryl group as the side chain. Our work led to the discovery of a number of BTZ derived compounds with potent antitubercular activity. The optimized compounds 6 and 38 exhibited MIC 47 and 30 nM, respectively. Compared to PBTZ169, both compounds displayed increased aqueous solubility and higher stability in human liver microsomes. This study suggested that an alternative side-chain modification strategy could be implemented to improve the druglike properties of the BTZ-based compounds.