N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide

Base Information

• Chemical Name: N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide
• CAS No.: 1258323-55-5
• Molecular Formula: C₂₄H₂₀ClN₃O₃S₂
• Molecular Weight: 498.026
• Mol file: 1258323-55-5.mol

Synonyms:N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide

Chemical Property of N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide

There total 3 articles about N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H14ClN3OS2 (901116-33-4) + 2-Methoxybenzoyl chloride (21615-34-9) → N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide (1258323-55-5)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2010.12.124

Reference yield:

4-chlorobenzylamine (104-86-9) → N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide (1258323-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane / 0 °C / Reflux

2: potassium carbonate / acetone / 4 h / Reflux

3: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2010.12.124

Reference yield:

2-chloro-N-(4-chlorobenzyl)acetamide (99585-88-3) → N-(2-(2-(4-chlorobenzylamino)-2-oxoethylthio)benzothiazol-6-yl)-2-methoxybenzamide (1258323-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 4 h / Reflux

2: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2010.12.124

upstream raw materials:

C₁₆H₁₄ClN₃OS₂

2-Methoxybenzoyl chloride

2-chloro-N-(4-chlorobenzyl)acetamide

4-chlorobenzylamine