Technology Process of ((E)-(3S,4R,5S,6R)-3,4,5,6-Tetrakis-benzyloxy-7-trityloxy-hept-1-enyl)-phosphonic acid diethyl ester
There total 6 articles about ((E)-(3S,4R,5S,6R)-3,4,5,6-Tetrakis-benzyloxy-7-trityloxy-hept-1-enyl)-phosphonic acid diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / pyridine, 4-dimethylaminopyridine / 4 h / 70 °C
2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h
3: 70 percent / calcium carbonate, aq. mercuric(II) chloride / acetonitrile / 3 h / Ambient temperature
4: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, cyclohexane, RT, 15 min, 2.) THF, cyclohexane, RT, 3 h
With
pyridine; dmap; sodium hydride; calcium carbonate; mercury dichloride; lithium hexamethyldisilazane;
In
acetonitrile;
DOI:10.1016/0040-4020(96)00380-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h
2: 70 percent / calcium carbonate, aq. mercuric(II) chloride / acetonitrile / 3 h / Ambient temperature
3: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, cyclohexane, RT, 15 min, 2.) THF, cyclohexane, RT, 3 h
With
sodium hydride; calcium carbonate; mercury dichloride; lithium hexamethyldisilazane;
In
acetonitrile;
DOI:10.1016/0040-4020(96)00380-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / pyridine, 4-dimethylaminopyridine / 4 h / 70 °C
2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h
3: 70 percent / calcium carbonate, aq. mercuric(II) chloride / acetonitrile / 3 h / Ambient temperature
4: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, cyclohexane, RT, 15 min, 2.) THF, cyclohexane, RT, 3 h
With
pyridine; dmap; sodium hydride; calcium carbonate; mercury dichloride; lithium hexamethyldisilazane;
In
acetonitrile;
DOI:10.1016/0040-4020(96)00380-8
