3-Fluoro-2-hydroxypropyl=benzoate

Base Information

• Chemical Name: 3-Fluoro-2-hydroxypropyl=benzoate
• CAS No.: 62522-72-9
• Molecular Formula: C₁₀H₁₁FO₃
• Molecular Weight: 198.194
• Mol file: 62522-72-9.mol

Synonyms:BENZOIC ACID,3-FLUORO-2-HYDROXYPROPYL ESTER;1-Benzoyloxy-3-fluorpropan-2-ol;1-Benzoyloxy-3-fluoropropan-2-ol;3-fluoro-1,2-propanediol 1-O-benzoate;

Chemical Property of 3-Fluoro-2-hydroxypropyl=benzoate

Chemical Property:

• Vapor Pressure: 9.01E-05mmHg at 25°C
• Boiling Point: 326°Cat760mmHg
• Flash Point: 151°C
• PSA: 46.53000
• Density: 1.21g/cm³
• LogP: 1.17380

Purity/Quality:

3-FLUORO-2-HYDROXYPROPYL BENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-2-hydroxypropyl=benzoate

There total 2 articles about 3-Fluoro-2-hydroxypropyl=benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

oxiran-2-ylmethyl benzoate (98760-25-9,120787-40-8,121787-43-7,13443-29-3) → 3-fluoro-1,2-propanediol 1,2-O-dibenzoate (142545-49-1) + 3-fluoro-1,2-propanediol 1-O-benzoate (62522-72-9)

Guidance literature:

With potassium hydrogen bifluoride; tetra-n-butylammonium dihydrogen trifluoride; at 120 ℃; for 7.5h; Mechanism;

DOI:10.1016/S0040-4020(01)92194-5

Reference yield:

3-fluoropropane-1,2-diol (453-16-7,30572-98-6) + benzoyl chloride (98-88-4) → 3-fluoro-1,2-propanediol 1-O-benzoate (62522-72-9)

Guidance literature:

With pyridine;

DOI:10.1021/jm00215a005

upstream raw materials:

3-fluoropropane-1,2-diol

benzoyl chloride

oxiran-2-ylmethyl benzoate