2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

Base Information

Chemical Name:2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester
CAS No.:1032297-57-6
Molecular Formula:C₂₁H₂₅NO₄S
Molecular Weight:387.5
Hs Code.:

Synonyms:2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

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Chemical Property of 2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

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Technology Process of 2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

There total 1 articles about 2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1032297-50-9
2-[phenyl-(tosylcarbamoyloxy)-methyl]-acrylic acid tert-butyl ester

: 1032297-57-6
2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

: 172656-88-1
2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

Guidance literature:: With C₅₄H₅₈N₄O₆; In dichloromethane; at 35 ℃; for 48h;
DOI:10.1002/chem.200701729

Reference yield: 55.0%

: 5162-44-7
1-bromo-4-butene

: 1032297-57-6
2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

: (S)-tert-butyl 2-((N-(but-3-en-1-yl)-4-methylphenylsulfonamido)-(phenyl)methyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 120h;
DOI:10.1016/j.tet.2017.06.054

Reference yield:

: 1032297-57-6
2-[phenyl-(toluene-4-sulfonylamino)-methyl]-acrylic acid tert-butyl ester

: (S)-tert-butyl 2-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate

: (R)-tert-butyl 2-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 4 h / Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 2: |Grubbs Olefin Metathesis;
DOI:10.1016/j.tet.2017.06.054