2(1H)-Isoquinolinecarboxylic acid, 1-[(4-aminophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-aminophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester
• CAS No.: 924651-73-0
• Molecular Formula: C₃₇H₃₆N₂O₈
• Molecular Weight: 636.701
• Mol file: 924651-73-0.mol

Synonyms:1-(4-amino-benzyl)-6,7-bis-ethoxycarbonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-aminophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-aminophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

There total 5 articles about 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-aminophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline (880475-00-3) → 1-(4-amino-benzyl)-6,7-bis-ethoxycarbonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 9H-fluoren-9-ylmethyl ester (924651-73-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 3102.89 Torr;

DOI:10.1016/j.bmc.2005.12.027

Reference yield:

2-[(9H-fluoren-9-yl)methoxycarbonyl]-6,7-dimethoxy-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline (880474-96-4) → 1-(4-amino-benzyl)-6,7-bis-ethoxycarbonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 9H-fluoren-9-ylmethyl ester (924651-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / BBr₃ / CH₂Cl₂ / cooling

2: 95 percent / pyridine / CH₂Cl₂ / 20 °C

3: 99 percent / H₂ / Pd-C / ethyl acetate / 4 h / 3102.89 Torr

With pyridine; hydrogen; boron tribromide; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2005.12.027

Reference yield:

2-[(9H-fluoren-9-yl)methoxycarbonyl]-6,7-dihydroxy-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline (880474-98-6) → 1-(4-amino-benzyl)-6,7-bis-ethoxycarbonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 9H-fluoren-9-ylmethyl ester (924651-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / pyridine / CH₂Cl₂ / 20 °C

2: 99 percent / H₂ / Pd-C / ethyl acetate / 4 h / 3102.89 Torr

With pyridine; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2005.12.027

upstream raw materials:

6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline

2-[(9H-fluoren-9-yl)methoxycarbonyl]-6,7-dimethoxy-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline

2-[(9H-fluoren-9-yl)methoxycarbonyl]-6,7-dihydroxy-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline

1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-nitrophenyl)methyl]isoquinoline

Downstream raw materials:

1-(4-amino-3-iodobenzyl)-6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1,2,3,4-tetrahydroisoquinoline

1-(4-azido-3-iodobenzyl)-6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1,2,3,4-tetrahydroisoquinoline