tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate

Base Information

• Chemical Name: tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate
• CAS No.: 1388891-87-9
• Molecular Formula: C₂₁H₂₉N₃O₃S
• Molecular Weight: 403.546

Synonyms:tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate

Chemical Property of tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate

There total 4 articles about tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-81-3) + methyl iodide (74-88-4) → tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(12),2(6),8,10-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-87-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 74.0%

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (300816-22-2) + tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate (400899-99-2) → tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(12),2(6),8,10-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-87-9)

Guidance literature:

tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.333333h; Inert atmosphere;

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine; In tetrahydrofuran; mineral oil; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

trans-tert-butyl 4-hydroxycyclohexylcarbamate (111300-06-2) → tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(12),2(6),8,10-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

trans-tert-butyl 4-hydroxycyclohexylcarbamate

tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

methyl iodide

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

Downstream raw materials:

(1r,4r)-N-benzyl-N-ethyl-4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexan-1-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1388891-87-9 tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send