C₃₃H₃₇N₅O₆

Base Information

• Chemical Name: C₃₃H₃₇N₅O₆
• CAS No.: 1147077-81-3
• Molecular Formula: C₃₃H₃₇N₅O₆
• Molecular Weight: 599.687
• Mol file: 1147077-81-3.mol

Synonyms:C₃₃H₃₇N₅O₆

Chemical Property of C₃₃H₃₇N₅O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₇N₅O₆

There total 6 articles about C₃₃H₃₇N₅O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-methyl-piperazine (109-01-3) + 2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid (1147077-79-9) → C33H37N5O6 (1147077-81-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 40 ℃; for 18h;

DOI:10.1021/jm201640m

Reference yield:

2-amino-8-methyl-4-(methylthio)-5H-indeno[1,2-d]pyrimidin-5-one (1228035-28-6) → C33H37N5O6 (1147077-81-3)

Guidance literature:

Multi-step reaction with 6 steps

1: dmap / N,N-dimethyl-formamide

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3: N-Bromosuccinimide; Phthalic acid dibutyl ester / benzene

4: 4-methylmorpholine N-oxide / acetonitrile / 18 h / 20 °C / Molecular sieve

5: potassium permanganate / water; acetone / 14 h / 55 °C

6: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 18 h / 40 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium permanganate; N-Bromosuccinimide; Phthalic acid dibutyl ester; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 2: Suzuki coupling;

DOI:10.1021/jm201640m

Reference yield:

C28H28BrN3O5 (1147077-78-8) → C33H37N5O6 (1147077-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methylmorpholine N-oxide / acetonitrile / 18 h / 20 °C / Molecular sieve

2: potassium permanganate / water; acetone / 14 h / 55 °C

3: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 18 h / 40 °C

With potassium permanganate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; acetone; acetonitrile;

DOI:10.1021/jm201640m

upstream raw materials:

1-methyl-piperazine

2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

C₂₈H₂₈BrN₃O₅

2-(bis(methylthio)methylene)-6-methyl-2,3-dihydro-1H-inden-1-one

Downstream raw materials:

JNJ-39928122