(R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

Base Information

Chemical Name:(R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate
CAS No.:1338046-00-6
Molecular Formula:C₂₀H₂₁NO₆S
Molecular Weight:403.456
Hs Code.:

Synonyms:(R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

Suppliers and Price of (R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

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Chemical Property of (R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

Chemical Property:

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Technology Process of (R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

There total 7 articles about (R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338045-99-0
(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

: 1338046-00-6
(R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.tetasy.2011.07.011

Reference yield:

: C₁₈H₁₉NO₅S

: 1338046-00-6
(R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetasy.2011.07.011

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1338046-00-6
(R)-((R)-3-benzyl-2-oxooxazolidin-4-yl)[4-(methylsulfonyl)phenyl]methyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: sulfuric acid / tetrahydrofuran; water / 10 h / Reflux

3.1: sodium tungstate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 20 °C

4.1: tert.-butylhydroperoxide; C₃H₇O^(1-)*C₃₄H₃₂N₂O₄^(2-)*V⁽³⁺⁾ / dichloromethane; water / 72 h / 0 °C

5.1: N,N-dimethyl-formamide / 10 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C

With tert.-butylhydroperoxide; sodium tungstate; sulfuric acid; C₃H₇O^(1-)*C₃₄H₃₂N₂O₄^(2-)*V⁽³⁺⁾; dihydrogen peroxide; sodium hydride; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.2: Grignard reaction / 1.3: Grignard reaction;
DOI:10.1016/j.tetasy.2011.07.011