(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Base Information

Chemical Name:(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one
CAS No.:1338045-99-0
Molecular Formula:C₁₈H₁₉NO₅S
Molecular Weight:361.419
Hs Code.:

Synonyms:(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Suppliers and Price of (R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

There total 6 articles about (R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₉NO₅S

: 1338045-99-0
(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2011.07.011

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1338045-99-0
(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: sulfuric acid / tetrahydrofuran; water / 10 h / Reflux

3.1: sodium tungstate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 20 °C

4.1: tert.-butylhydroperoxide; C₃H₇O^(1-)*C₃₄H₃₂N₂O₄^(2-)*V⁽³⁺⁾ / dichloromethane; water / 72 h / 0 °C

5.1: N,N-dimethyl-formamide / 10 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

With tert.-butylhydroperoxide; sodium tungstate; sulfuric acid; C₃H₇O^(1-)*C₃₄H₃₂N₂O₄^(2-)*V⁽³⁺⁾; dihydrogen peroxide; sodium hydride; magnesium; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.2: Grignard reaction / 1.3: Grignard reaction;
DOI:10.1016/j.tetasy.2011.07.011

Reference yield:

: 125872-64-2
(E)-3-[4-(methylsulfonyl)phenyl]prop-2-en-1-ol

: 1338045-99-0
(R)-3-benzyl-4-[(S)-hydroxy(4-methylsulfonylphenyl)methyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butylhydroperoxide; C₃H₇O^(1-)*C₃₄H₃₂N₂O₄^(2-)*V⁽³⁺⁾ / dichloromethane; water / 72 h / 0 °C

2: N,N-dimethyl-formamide / 10 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

With tert.-butylhydroperoxide; C₃H₇O^(1-)*C₃₄H₃₂N₂O₄^(2-)*V⁽³⁺⁾; sodium hydride; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2011.07.011