[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

Base Information

Chemical Name:[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol
CAS No.:1383919-11-6
Molecular Formula:C₁₂H₁₄ClNO₄S
Molecular Weight:303.766
Hs Code.:

Synonyms:[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

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Chemical Property of [2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

Chemical Property:

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Technology Process of [2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

There total 1 articles about [2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid

: 1383919-11-6
[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

Guidance literature:: methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; for 2h;

With sodium tetrahydroborate; water; In tetrahydrofuran; at 0 - 20 ℃; for 19h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield:

: 1383919-11-6
[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

: 10387-40-3
potassium thioacetate

: 1383919-12-7
S-[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)]-benzyl ester

Guidance literature:: [2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol; With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 3h;

potassium thioacetate; In acetone; at 20 ℃; for 3h;

Reference yield:

: 1383919-11-6
[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-methanol

: 1383919-13-8
3-[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)benzylsulfanylmethyl]-pyrazine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C

1.2: 3 h / 20 °C

2.1: potassium carbonate / methanol / 0.33 h / 20 °C

2.2: 3 h / Reflux

With phosphorus tribromide; potassium carbonate; In methanol; dichloromethane;