7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

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Chemical Name:7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol
CAS No.:1383919-10-5
Molecular Formula:C₁₈H₁₆ClN₃O₆S₂
Molecular Weight:469.927
Hs Code.:

Synonyms:7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

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Chemical Property of 7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

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Technology Process of 7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

There total 4 articles about 7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383919-14-9
3-[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)-phenylmethanesulfonylmethyl]-pyrazine-2-carboxylic acid methyl ester

: 1383919-10-5
7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

: methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid

: 1383919-10-5
7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h

1.2: 19 h / 0 - 20 °C

1.3: pH 2

2.1: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C

2.2: 3 h / 20 °C

3.1: potassium carbonate / methanol / 0.33 h / 20 °C

3.2: 3 h / Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

With oxalyl dichloride; phosphorus tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1383919-12-7
S-[2-chloro-4-methanesulfonyl-3-(3-methyl-4,5-dihydro-isoxazol-5-yl)]-benzyl ester

: 1383919-10-5
7-[2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonyl-phenyl]-6,6-dioxo-5H-thiopyrano[3,4-b]pyrazin-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 0.33 h / 20 °C

1.2: 3 h / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;