7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

Base Information

Chemical Name:7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine
CAS No.:1448510-87-9
Molecular Formula:C₆₄H₆₂N₈O₈
Molecular Weight:1071.25
Hs Code.:

Synonyms:7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

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Chemical Property of 7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

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Technology Process of 7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

There total 6 articles about 7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1448511-03-2
N-(4-methoxytrityl)succinyl histamine

: 637330-18-8
4-amino-5-(prop-2-ynylamino)-7-(5'-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine

: 1448510-87-9
7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c3ob40842f

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1448510-87-9
7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 15 h / 20 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 12 h / 20 °C / Inert atmosphere

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c3ob40842f

Reference yield:

: 178420-75-2
7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-[3-(3-trifluoroacetamido)prop-1-ynyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 1448510-87-9
7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 15 h / 20 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 12 h / 20 °C / Inert atmosphere

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c3ob40842f