ethyl 5-oxo-3-phenylhexanoate

Base Information

• Chemical Name: ethyl 5-oxo-3-phenylhexanoate
• CAS No.: 127053-50-3
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 127053-50-3.mol

Synonyms:ethyl 5-oxo-3-phenylhexanoate

Chemical Property of ethyl 5-oxo-3-phenylhexanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 5-oxo-3-phenylhexanoate

There total 18 articles about ethyl 5-oxo-3-phenylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(3-Methyl-5-oxo-2,5-dihydro-isoxazol-4-yl)-3-phenyl-propionic acid ethyl ester → ethyl 5-oxo-3-phenylhexanoate (127053-50-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 6h; under 2660 Torr;

Reference yield: 81.0%

ethanol (64-17-5) + 5-acetyl-6-methyl-4-phenyl-3,4-dihydro-2H-pyran-2-one (1261085-76-0) → ethyl 5-oxo-3-phenylhexanoate (127053-50-3)

Guidance literature:

ethanol; 5-acetyl-6-methyl-4-phenyl-3,4-dihydro-2H-pyran-2-one; at 20 ℃;

With methanol; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃; for 24h;

DOI:10.1002/ejoc.202000858

Reference yield: 60.0%

ethyl tert-butyldimethylsilyl malonate + (E)-benzalacetone (1896-62-4) → ethyl 5-oxo-(3R)-phenylhexanoate (127053-50-3,137654-28-5)

Guidance literature:

ethyl tert-butyldimethylsilyl malonate; (E)-benzalacetone; With 9-epi-9-amino-9-deoxyquinine; In toluene; at 20 ℃; for 48h;

With tetrabutyl ammonium fluoride; In water; dimethyl sulfoxide; for 1h; Reagent/catalyst; Solvent; enantioselective reaction; Reflux;

DOI:10.5012/bkcs.2013.34.9.2569

upstream raw materials:

5-oxo-3-phenylhexanoic acid

ethanol

1-bromo-4,4-dimethylpentan-3-one

3-bromo-1-phenylpropan-1-one

Downstream raw materials:

5-phenyl-cyclohexane-1,3-dione