(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid

Base Information

• Chemical Name: (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid
• CAS No.: 148716-39-6
• Molecular Formula: C₁₉H₂₂NO₆P
• Molecular Weight: 391.361
• Mol file: 148716-39-6.mol

Synonyms:(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid

Chemical Property of (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid

There total 11 articles about (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R,R,S,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-methyloxyphosphinyl)propanoic acid tert-butyl ester → (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid (148716-39-6)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; for 14h;

DOI:10.1021/jo0156363

Reference yield:

(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester (181506-69-4) → (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid (148716-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KOH / diethyl ether; H₂O / 0.25 h / 0 °C

1.2: 85 percent / diethyl ether / 0 °C

2.1: 0.35 N aq.NaOH / methanol / 0.67 h

With potassium hydroxide; sodium hydroxide; In methanol; diethyl ether; water;

DOI:10.1021/jo0156363

Reference yield:

(R,R,S,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester → (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid (148716-39-6)

Guidance literature:

With sodium hydroxide; In methanol; for 0.666667h;

DOI:10.1021/jo0156363

upstream raw materials:

3-[(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionic acid methyl ester

(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester

(R,S)-((1-amino)-2-phenylethyl) phosphinic acid

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid