(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester

Base Information

• Chemical Name: (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester
• CAS No.: 181506-69-4
• Molecular Formula: C₂₁H₂₆NO₆P
• Molecular Weight: 419.414
• Mol file: 181506-69-4.mol

Synonyms:(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester

Chemical Property of (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester

There total 8 articles about (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid (115961-49-4) + ethyl acrylate (140-88-5,9003-32-1) → (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester (181506-69-4)

Guidance literature:

With 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction; 1) 110 deg C, 1 h, 2) 90 deg C, 4 h;

DOI:10.1021/jo9603439

Reference yield:

(R,R,S,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)benzyloxyphosphinyl)propanoic acid ethyl ester → (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester (181506-69-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 24h; Further Variations:; Solvents; times; Product distribution;

DOI:10.1021/jo0156363

Reference yield:

(R,R,S,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)diphenylmethyloxyphosphinyl)propanoic acid ethyl ester → (R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester (181506-69-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 0.0833333h; Product distribution;

DOI:10.1021/jo0156363

upstream raw materials:

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

ethyl acrylate

Downstream raw materials:

3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester

3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)-hydroxyphosphinyl) propanoic acid