N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide

Base Information

• Chemical Name: N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide
• CAS No.: 183320-22-1
• Molecular Formula: C₃₄H₅₀BrN₅O₇Si₂
• Molecular Weight: 776.875

Synonyms:N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property of N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide

There total 8 articles about N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide (183320-22-1)

Guidance literature:

Multi-step reaction with 3 steps

3: H⁺

With hydrogen cation;

Reference yield:

8-bromoadenosine (2946-39-6) → N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide (183320-22-1)

Guidance literature:

Multi-step reaction with 3 steps

3: H⁺

With hydrogen cation;

Reference yield:

8-bromo-9-(3,5-O-tetraisopropyldisiloxane-1,3-diyl-β-D-ribofuranosyl)adenine (165190-34-1) → N-{8-Bromo-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide (183320-22-1)

Guidance literature:

Multi-step reaction with 2 steps

2: H⁺

With hydrogen cation;

upstream raw materials:

benzoyl chloride

2'-O-(tetrahydropyran-2-yl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-8-bromoadenosine

3,4-dihydro-2H-pyran

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Downstream raw materials:

5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine

5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine 3'-H-phosphonate

5'-O-dimethoxytrityl-2'-O-(tetrahydropyran-2-yl)-N⁶-benzoyl-8-aminoadenosine 3'-H-phosphonate

2'-O-tetrahydropyranyl-N⁶-benzoyl-8-bromoadenosine

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