[1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

Base Information

Chemical Name:[1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate
CAS No.:1353678-77-9
Molecular Formula:C₂₆H₃₇N₃O₄Si
Molecular Weight:483.683
Hs Code.:

Synonyms:[1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

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Chemical Property of [1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

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Technology Process of [1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

There total 12 articles about [1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353678-74-6
1-ethyl-7-methyl-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one 4-oxide

: 108-24-7
acetic anhydride

: 1353678-77-9
[1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

Guidance literature:: at 80 ℃; for 2h;

Reference yield:

: 3430-27-1
3-amino-4-methylpyridine

: 1353678-77-9
[1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride; dihydrogen peroxide / water / 1 h / 0 - 20 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

3: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / isopropyl alcohol; toluene / 24 h / 100 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 50 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

6: N,N-dimethyl-formamide / 1 h / 20 °C

7: trifluoroacetic anhydride; urea hydrogen peroxide adduct / ethyl acetate / 0 °C

8: 2 h / 80 °C

With hydrogenchloride; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; urea hydrogen peroxide adduct; caesium carbonate; trifluoroacetic anhydride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 133627-45-9
3-Amino-2-chloro-4-methylpyridine

: 1353678-77-9
[1-ethyl-2-oxo-3-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]methyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

2: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / isopropyl alcohol; toluene / 24 h / 100 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 50 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

6: trifluoroacetic anhydride; urea hydrogen peroxide adduct / ethyl acetate / 0 °C

7: 2 h / 80 °C

With hydrogen; sodium hexamethyldisilazane; urea hydrogen peroxide adduct; caesium carbonate; trifluoroacetic anhydride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;