3430-27-1

Basic information

• Product Name: 3-Amino-4-methylpyridine
• Synonyms: 4-METHYLPYRIDIN-3-AMINE;4-METHYL-PYRIDIN-3-YLAMINE;4-METHYL-3-PYRIDINAMINE;3-AMINO-4-PICOLINE;3-AMINO-4-METHYLPYRIDINE;IFLAB-BB F1957-0029;3-AMINO-4-METHYLPYRIDINE 98%;3-Pyridinamine, 4-methyl-
• CAS NO: 3430-27-1
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• EINECS: -0
• Product Categories: VARIOUSAMINE;Pyridine;Heterocycles;Heterocyclic Compound;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Pyridines;Pyridines derivates;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Boronic Acid;C6;Heterocyclic Building Blocks;Pyridine Series;Aromatics
• Mol File: 3430-27-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 102-106°C
• Boiling Point: 254°C
• Flash Point: 254°C
• Appearance: /
• Density: 1.0275 (estimate)
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 6.83±0.18(Predicted)
• Sensitive: Hygroscopic
• BRN: 107792
• CAS DataBase Reference: 3-Amino-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methylpyridine(3430-27-1)
• EPA Substance Registry System: 3-Amino-4-methylpyridine(3430-27-1)

Safety Data

• Hazard Codes: T,Xn
• Statements: 23/24/25-36/37/38-41-37/38-22-20/21/22
• Safety Statements: 26-36/37/39-45-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 3430-27-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8N2/c1-5-2-3-8-4-6(5)7/h2-4H,7H2,1H3

Upstream product

• 7250-52-4 4-methyl-3-pyridinecarboxamide 
• 5832-44-0 3-nitro-4-methylpyridine 
• 7440-44-0 pyrographite 
• 7440-05-3 palladium 
• 108-89-4 picoline 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 695-34-1 2-Amino-4-methylpyridine 
• 23056-45-3 2-bromo-3-nitro-4-methyl pyridine 
• 21901-18-8 2-hydroxy-4-methyl-3-nitropyridine 
• 6635-86-5 2-amino-4-methyl-3-nitropyridine 
• 21901-40-6 2-amino-5-nitro-4-picoline 
• 21901-41-7 2-hydroxy-4-methyl-5-nitropyridine 
• 6316-67-2 3-pyridinecarboxylic acid,4-methyl-hydrazide 
• 55314-29-9 4-methylnicotinic acid ethyl ester 

Downstream Products

• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 
• 399-88-2 3-fluoro-4-methylpyridine 
• 38749-96-1 3-iodo-4-methyl-pyridine 
• 928263-93-8 3-hydrazino-4-methylpyridine hydrochloride 
• 794569-03-2 3-hydrazino-4-methylpyridine 
• 1148050-83-2 C₁₉H₁₅F₂N₅O 
• 471909-36-1 3-fluoroisonicotinaldehyde oxime 
• 40273-47-0 3-fluoropyridine-4-carbaldehyde 
• 1228879-37-5 (3R,4R)-rel-N,4-dimethyl-1-benzyl-3-piperidinamine dihydrochloride 
• 19352-29-5 methyl-4 phenyl-3 pyridine 
• 1405129-24-9 tert-butyl ((3R,4R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate 
• 1405129-26-1 tert-butyl ((3R,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate 
• 1405129-25-0 tert-butyl ((3S,4R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate 
• 1405129-23-8 tert-butyl ((3S,4S)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-4-methylpiperidin-3-yl)carbamate 

Relevant articles and documents

Preparation method of (S)-4- (C)-3-(S)-bromopyridine (bromopyridine) (by machine translation)

The method disclosed by the invention has, the beneficial, effects :(1) that 4 - the reaction conditions are mild, the treatment is easy 4 - the method is easy to, operate, the, treatment, is easy . and the method is, easy to, operate 4 - and easy to ;(2) operate 4 - pH, 4 . (by machine translation)

A 4 - methyl -3 - bromo pyridine preparation method

The invention belongs to the field of organic synthesis, in particular to a 4 - methyl - 3 - bromo pyridine method, comprises the following steps: (1) to 4 - methyl - 3 - nitro pyridine as raw materials, methanol as solvent, under the effects of catalyst hydrogenation reduction, filtered, the filtrate is concentrated, be 4 - methyl - 3 - aminopyridine; (2) the 4 - methyl - 3 - aminopyridine reacts with acid to form the salt cooling to - 10 °C - 0 °C, [...], [...] sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, a 4 - methyl - 3 - bromo pyridine. The beneficial effect of the invention is: mild reaction conditions, is easy to operate, after treatment is simple, and easy to enlarge production, is extremely suitable for industrial production; good catalytic effect, high yield; low prices of raw materials, the production cost is low.

A 3-amino-4-methylpyridine preparation method

The invention belongs to the field of organic chemical synthesis and particularly relates to a synthesis method of 3-amino-4-methylpyridine which is an intermediate of an anti-AIDS drug nevirapine. According to the method, 4-methylpyridine-3-boronic acid is used as a raw material, an inorganic amide is used as an ammonia source and obtain3-amino-4-methylpyridine is prepared through one-step reaction in the presence of metal oxide as a catalyst. The preparation method is still simple and provides a new way for novel and efficient synthesis of 3-amino-4-methylpyridine and the disadvantages of long traditional route, low yield and severe reaction conditions are overcome.