methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Base Information

Chemical Name:methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate
CAS No.:124749-73-1
Molecular Formula:C₂₆H₂₈ClF₃N₄O₅S
Molecular Weight:601.046
Hs Code.:

Synonyms:methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

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Chemical Property of methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

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Technology Process of methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

There total 11 articles about methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 125665-66-9
5-methyl-2-(trifluoromethanesulfonamido)benzoyl chloride

: 114772-05-3
methyl 2-butyl-4-chloro-1-(4-aminobenzyl)-imidazole-5-acetate

: 124749-73-1
methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 25 ℃; for 24h;
DOI:10.1021/jm00167a007

Reference yield:

: 18595-16-9
2-amino-5-methylbenzoic acid methyl ester

: 124749-73-1
methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 3 h / -78 - -40 °C

2: 95 percent / 1 M NaOH / 2 h / Heating

3: 88 percent / thionyl chloride / 3 h / Heating

4: 61 percent / NaHCO₃ / CH₂Cl₂ / 24 h / 25 °C

With sodium hydroxide; thionyl chloride; sodium hydrogencarbonate; triethylamine; In dichloromethane;
DOI:10.1021/jm00167a007

Reference yield:

: 125665-65-8
5-methyl-2-(trifluoromethanesulfonamido)benzoic acid

: 124749-73-1
methyl 2-n-butyl-4-chloro-1-<<4-<5-methyl-2-(trifluoromethylsulfonamido)benzamido>phenyl>methyl>imidazole-5-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / thionyl chloride / 3 h / Heating

2: 61 percent / NaHCO₃ / CH₂Cl₂ / 24 h / 25 °C

With thionyl chloride; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1021/jm00167a007