(E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene

Base Information

• Chemical Name: (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene
• CAS No.: 1574533-15-5
• Molecular Formula: C₂₃H₂₀O₄S
• Molecular Weight: 392.475
• Mol file: 1574533-15-5.mol

Synonyms:(E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene

Chemical Property of (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene

There total 3 articles about (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(E)-1-((2-bromo-2-phenylvinyl)sulfonyl)-4-methylbenzene (52920-45-3) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene (1574533-15-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.tet.2014.01.071

Reference yield:

phenylacetylene (536-74-3) → (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene (1574533-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; [2,2]bipyridinyl; potassium bromide / acetic acid / 18 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; N,N-dimethyl-formamide / 20 h / 100 °C / Inert atmosphere

With [2,2]bipyridinyl; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium bromide; In water; acetic acid; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tet.2014.01.071

Reference yield:

sodium tosylate (657-84-1) → (E)-2-(4'-methoxycarbonylphenyl)-1-(4'-methylphenylsulfonyl)-2-phenylethene (1574533-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; [2,2]bipyridinyl; potassium bromide / acetic acid / 18 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; N,N-dimethyl-formamide / 20 h / 100 °C / Inert atmosphere

With [2,2]bipyridinyl; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium bromide; In water; acetic acid; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tet.2014.01.071

upstream raw materials:

(E)-1-((2-bromo-2-phenylvinyl)sulfonyl)-4-methylbenzene

4-methoxycarbonylphenylboronic acid

phenylacetylene

sodium tosylate