657-84-1

Basic information

• Product Name: Sodium p-toluenesulfonate
• Synonyms: naxonatehydrotrope;para-toluenesulfonicacid,sodiumsalt;p-toluenesulfonicacid,sodiumsalt,mixtureofisomers;sodiumparatoluenesulphonate;sodiump-methylbenzenesulfonate;sodiump-toluenesulphonate;sodiump-tolylsulfonate;sodiumtoluene-p-sulphonate
• CAS NO: 657-84-1
• Molecular Formula: C₇H₇O₃S*Na
• Molecular Weight: 194.18
• EINECS: 211-522-5
• Product Categories: Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonic/Sulfinic Acid Salts;Sulfur Compounds;dye chemistry,hydrotropic solvent
• Mol File: 657-84-1.mol
• Article Data: 31

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 140oC at 20 MM HG
• Flash Point: 500 °C
• Appearance: White to off-white/Powder
• Density: 1.55 g/cm3 (20℃)
• Vapor Pressure: <1 hPa (20 °C)
• Storage Temp.: Store below +30°C.
• Solubility: 818g/l soluble
• PKA: 6.59[at 20 ℃]
• Water Solubility: soluble
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,9533
• BRN: 3637479
• CAS DataBase Reference: Sodium p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium p-toluenesulfonate(657-84-1)
• EPA Substance Registry System: Sodium p-toluenesulfonate(657-84-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36
• WGK Germany: 1
• RTECS: XT7350000
• Hazardous Substances Data: 657-84-1(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

Different sources of media describe the Uses of 657-84-1 differently. You can refer to the following data:
1. Usually used as a supporting electrolyte for depositing polypyrrole membranes, ang also used as a solute to study the performance of resin particles.
2. Sodium?p-Toluenesulfonate can be used for high-efficiency for cleaning explosives.
3. Sodium p-toluenesulfonate was used as a supporting electrolyte for depositing polypyrrole membranes. It was also used as a solute to study the performance of resin particles.

Flammability and Explosibility

Nonflammable

Purification Methods

Dissolve it in distilled water, filter it to remove insoluble impurities and evaporate it to dryness. Then recrystallise it from MeOH or EtOH, and dry it at 110o. Its solubility in EtOH is not high (maximum 2.5%), so that Soxhlet extraction with EtOH may be preferable. Sodium p-toluenesulfonate has also been crystallised from Et2O and dried under a vacuum at 50o. [Beilstein 11 I 4, 11 II 6, cf Gibson & Reid J Chem Soc 879 1923.]

InChI:InChI=1/C7H8O3S.Na.H/c1-6-2-4-7(5-3-6)11(8,9)10;;/h2-5H,1H3,(H,8,9,10);;/rC7H8O3S.HNa/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);1H

Synthetic route

magnesium para-toluenesulfonate → sodium tosylate (657-84-1)

Conditions	Yield
With sodium carbonate In water at 5 - 90℃; for 4h;	99%

toluene-4-sulfonic acid (104-15-4) → di(p-tolyl) disulfide (103-19-5) + sodium tosylate (657-84-1)

Conditions	Yield
With trifluoroacetic anhydride; sodium iodide In acetone for 13h; Ambient temperature;	A 6% B 84%

2,2,2-Trifluoroethyl p-toluenesulfonate (433-06-7) → sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydroxide In methanol; dichloromethane at 20℃; for 16h;	82%

toluene-4-sulfonic acid 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester (67674-48-0) → sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydroxide In methanol; dichloromethane at 20℃; for 16h;	82%

toluene-4-sulfonic acid 2,2,2-trichloro-ethyl ester (57392-61-7) → sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydroxide In methanol; dichloromethane at 20℃; for 16h;	80%

toluene-4-sulfonic acid phenyl ester (640-60-8) → sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydroxide In methanol; dichloromethane at 20℃; for 16h;	72%

C44H52NO14S(1-)*Na(1+) → sodium tosylate (657-84-1) + rifamycin S (13553-79-2)

Conditions	Yield
In ethyl acetate at 70℃; for 5.75h; Product distribution;	A 71% B 46%

toluene-4-sulfonic acid 2,2,2-trifluoro-1-phenyl-ethyl ester (13652-13-6) → sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydroxide In methanol; dichloromethane at 20℃; for 16h;	65%

monochloronitromethane (1794-84-9) + sodium 4-methylbenzenesulfinate (824-79-3) → di(p-tolyl) disulfide (103-19-5) + nitromethyl p-tolyl sulfone (51351-89-4) + sodium tosylate (657-84-1) + p-tolylsulphenyl toluene-p-sulphonate

Conditions	Yield
With nitromethane In N,N-dimethyl-formamide for 24h; Ambient temperature;	A 2% B 7% C 64% D 26%

methanol (67-56-1) + nitromethane anion (18137-96-7) + p-toluenesulfonyl fluoride (455-16-3) → sodium tosylate (657-84-1) + methyl p-toluene sulfonate (80-48-8)

Conditions	Yield
at 20℃; for 20h;	A 54% B 37%

ethanol (64-17-5) + toluene-p-sulfonyl bromide (1950-69-2) → sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
In water at 23℃; for 24h;	A 47% B 51%

toluene-p-sulfonyl bromide (1950-69-2) → sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
In ethanol; water at 23℃; for 24h;	A 47% B 51%

ethanol (64-17-5) + sodium 4-methylbenzenesulfinate (824-79-3) → bis(4-methylphenyl)disulfone (10409-07-1) + nitromethyl p-tolyl sulfone (51351-89-4) + sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
With bromonitromethane In water at 24℃; for 2h;	A 15% B 24% C 42% D 18%

bromonitromethane (563-70-2) + sodium 4-methylbenzenesulfinate (824-79-3) → bis(4-methylphenyl)disulfone (10409-07-1) + nitromethyl p-tolyl sulfone (51351-89-4) + sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
In ethanol; water at 24℃; for 2h;	A 15% B 24% C 42% D 18%

sodium 4-methylbenzenesulfinate (824-79-3) → bis(4-methylphenyl)disulfone (10409-07-1) + nitromethyl p-tolyl sulfone (51351-89-4) + sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
With bromonitromethane In ethanol; water at 24℃; for 2h;	A 15% B 24% C 42% D 18%

toluene-p-sulfonyl bromide (1950-69-2) + sodium nitromethane (25854-38-0) → bis(4-methylphenyl)disulfone (10409-07-1) + nitromethyl p-tolyl sulfone (51351-89-4) + sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
In ethanol; water at 23℃; for 24h; Further byproducts given;	A 17% B 8% C 41% D 30%

toluene-p-sulfonyl bromide (1950-69-2) → bis(4-methylphenyl)disulfone (10409-07-1) + nitromethyl p-tolyl sulfone (51351-89-4) + sodium tosylate (657-84-1) + ethyl ester of p-toluenesulfonic acid (80-40-0)

Conditions	Yield
With sodium nitromethane In ethanol; water at 23℃; for 24h; Further byproducts given;	A 17% B 8% C 41% D 30%

2-bromo-2-nitropropane (5447-97-2) + sodium 4-methylbenzenesulfinate (824-79-3) → α-nitroisopropyl p-tolyl sulfone (21272-86-6) + sodium tosylate (657-84-1) + p-tolylsulphenyl toluene-p-sulphonate

Conditions	Yield
In N,N-dimethyl-formamide for 0.333333h;	A 31% B 36% C 15%

(2,12-dimethyl-3,11-bis(1-(methylamino)ethylidene)-1,5,9,13-tetraazacyclohexadeca-1,4,9,12-tetraene-κ4N)nickel(II) hexafluorophosphate + decane-1,10-diyl bis(4-methylbenzenesulfonate) (36247-33-3) → {(2,3,14,15,17,23-hexamethyl-3,14,18,22,25,29-hexaazabicyclo{14.7.7}triaconta-1,15,17,22,24,29-hexaene-κ(4)N)nickel(II)} hexafluorophosphate*acetonitrile + sodium tosylate (657-84-1)

Conditions	Yield
With Na; MeOH In tetrahydrofuran; acetonitrile simultaneous addn. of solns. of Ni-complex and Na/MeOH to boiling MeCN (6 h), refluxing (36 h, pptn.), cooling to room temp.; chromy., crystn. (MeCN/MeOH); elem.anal.;	A 36% B n/a

(2,12-dimethyl-3,11-bis(1-(methylamino)ethylidene)-1,5,9,13-tetraazacyclohexadeca-1,4,9,12-tetraene-κ4N)nickel(II) hexafluorophosphate + nonane-1,9-diyl bis(4-methylbenzenesulfonate) (73992-42-4) → {(2,3,13,14,16,22-hexamethyl-3,13,17,21,24,28-hexaazabicyklo{13.7.7}nonacosa-1,14,16,21,23,28-hexaene-κ(4)N)nickel(II)} hexafluorophosphate + sodium tosylate (657-84-1)

Conditions	Yield
With Na; MeOH In acetonitrile simultaneous addn. of solns. of Ni-complex and Na/MeOH to boiling MeCN (over 4 h), refluxing (24 h, pptn.), cooling to room temp.; filtration, volume reduction, repeated chromy. (Al2O3,MeCN), EtOH addn., crystn. (12 h, freezer), washing (EtOH), drying (vac.); elem. anal.;	A 36% B n/a

butyl para-toluenesulfonate (778-28-9) → 1-bromo-butane (109-65-9) + sodium tosylate (657-84-1)

Conditions	Yield
With cetyltrimethylammonim bromide; sodium bromide In water at 25℃; Rate constant; Equilibrium constant; Kinetics;
With sodium bromide In water at 25℃; Rate constant;
With (CTA)2SO4; sodium bromide In water at 25℃; Rate constant;

butyl para-toluenesulfonate (778-28-9) → n-Butyl chloride (109-69-3) + sodium tosylate (657-84-1)

Conditions	Yield
With cetyltrimethylammonium chloride; sodium chloride In water at 25℃; Rate constant; Equilibrium constant; Kinetics;
With sodium chloride In water at 25℃; Rate constant;
With (CTA)2SO4; sodium chloride In water at 25℃; Rate constant;

chlorosulfonate de trimethylsilyle (4353-77-9) + 4-tolyltrimethylstannane (937-12-2) → sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydrogencarbonate 1) CCl4, rt, 1 h, 2) H2O, 20 min; Yield given. Multistep reaction;

thiophenolate (13133-62-5) + toluene-4-sulfonic acid 2-isocyano-ethyl ester (20647-85-2) → sodium tosylate (657-84-1) + (2-Isocyano-ethylsulfanyl)-benzene (3126-28-1)

Conditions	Yield
With sodium ethanolate Rate constant; Product distribution; multistep reaction, 1.) ethanol, 25 deg C; 2.) ethanol;

p-tolylsulfonylmethyl p-toluenesulfonate (14894-58-7) → formaldehyd (50-00-0) + sodium tosylate (657-84-1) + sodium 4-methylbenzenesulfinate (824-79-3)

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In water at 32.1℃; Rate constant; Mechanism; oder SDS, Igepal catalysis (25 deg C); solvolysis in H2O, H2O-dioxane;

N-methyl-N-nitrosotoluene-p-sulfonamide (80-11-5) → diazomethane (186581-53-3, 908094-01-9) + sodium tosylate (657-84-1)

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In ethanol at 25℃;
With sodium hydroxide; sodium dodecyl-sulfate In ethanol at 25℃; Kinetics; other micellar aggregates; other solvent;

α-p-Tolylsulfonylbenzyl-p-toluenesulfonat (62586-47-4) → sodium tosylate (657-84-1) + benzaldehyde (100-52-7) + sodium 4-methylbenzenesulfinate (824-79-3)

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In water at 32.1℃; Rate constant; Mechanism;

1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) + sodium phenylsulfonate (515-42-4) → sodium tosylate (657-84-1) + α-phenylsulfonyloxyacetophenone (98475-06-0)

Conditions	Yield
With 18-crown-6 ether In sulfolane at 50℃; Rate constant; Equilibrium constant;

Toluene-4-sulfonic acid 4-nitro-benzenesulfonylmethyl ester (31081-08-0) → formaldehyd (50-00-0) + sodium tosylate (657-84-1) + sodium 4-nitrobenzenesulfinate (15959-31-6)

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In water at 32.1℃; Rate constant; Mechanism; solvolysis in H2O-dioxane;

C42H60N4(4+)*C7H7O3S(1-)*4Cl(1-)*Na(1+) (121625-38-5) → sodium tosylate (657-84-1) + QCP44 (103901-40-2)

Conditions	Yield
Equilibrium constant;

sodium tosylate (657-84-1) → p-toluenesulfonyl iodide (1950-78-3)

Conditions	Yield
With iodine	100%

sodium tosylate (657-84-1) + 2,2-difluoro-1,3-dimethyl-imidazolidine (220405-40-3) → 2-fluoro-1,3-dimethylimidazolinium p-toluenesulfonate (960508-05-8)

Conditions	Yield
In acetonitrile at 0 - 30℃; for 3h; Product distribution / selectivity;	100%
In [D3]acetonitrile at 20 - 30℃; for 3h; Product distribution / selectivity;

sodium tosylate (657-84-1) + (8S,9R)-(-)-N-benzylcinchonidinium chloride (69221-14-3, 69257-04-1, 95189-65-4) → N-9-benzylcinchonidinium p-toluenesulfonate (1092983-01-1)

Conditions	Yield
In dichloromethane; water	100%

18-crown-6 ether (17455-13-9) + sodium tosylate (657-84-1) → C12H24O6*C7H7O3S(1-)*Na(1+)

Conditions	Yield
In methanol at 60℃; for 1h;	100%

dibenzo-18-crown-6 (14187-32-7) + sodium tosylate (657-84-1) → C20H24O6*C7H7O3S(1-)*Na(1+)

Conditions	Yield
In methanol at 60℃; for 1h;	100%

p-N,N-dimethylaminobenzamidopropyl(dimethyl)(lauryl)ammonium chloride (849699-52-1) + sodium tosylate (657-84-1) → (p-methoxycinnamidopropyl)dimethylamine (104040-44-0)

Conditions	Yield
In water	99.93%

p-methoxy cinnamidopropyldimethyllauryl ammonium chloride (104024-25-1) + sodium tosylate (657-84-1) → p-methoxy cinnamidopropyldimethyllauryl ammonium tosylate

Conditions	Yield
In water	99.83%

sodium tosylate (657-84-1) + 1-phenyl-acetone (103-79-7) → 1-phenyl-1-tosylpropan-2-one (14195-17-6)

Conditions	Yield
With iodine; triethylamine In methanol at 20℃; for 6h;	98%

[(bpy)PdIV(CH2CMe2-o-C6H4)(F)(OTf)] + sodium tosylate (657-84-1) + tetramethylammonium toluene-p-sulphonate (3983-91-3) → C27H27FN2O3PdS

Conditions	Yield
In [D3]acetonitrile at 25℃; for 12h;	98%

sodium tosylate (657-84-1) + 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride (4568-71-2) → 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium paratoluenesulfonate

Conditions	Yield
In water at 20℃; for 4h; Inert atmosphere;	98%

norborn-2-ene (498-66-8) + sodium tosylate (657-84-1) → bicyclo[2.2.1]heptan-2-yl(p-tolyl)sulfane

Conditions	Yield
With sulfuric acid; triphenylphosphine In water at 50℃; for 10h;	98%

titanium(IV) isopropylate (546-68-9) + water (7732-18-5) + sodium tosylate (657-84-1) + citric acid (77-92-9) → 3C6H5O7(3-)*Ti(4+)*5Na(1+)*19.5H2O

Conditions	Yield
Stage #1: titanium(IV) isopropylate; water; citric acid In tetrahydrofuran at 90℃; for 1h; Stage #2: sodium tosylate With sodium hydroxide In tetrahydrofuran pH=4.75;	98%

(4-methoxy-3-(trifluoromethyl)phenyl)boronic acid (149507-36-8) + 2-(diacetoxyiodo)mesitylene (33035-41-5) + sodium tosylate (657-84-1) → C17H17F3IO(1+)*C7H7O3S(1-)

Conditions	Yield
Stage #1: (4-methoxy-3-(trifluoromethyl)phenyl)boronic acid With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.166667h; Sealed tube; Inert atmosphere; Stage #2: 2-(diacetoxyiodo)mesitylene In dichloromethane at 0 - 20℃; Sealed tube; Inert atmosphere; Stage #3: sodium tosylate In dichloromethane; water for 0.005h; Inert atmosphere;	98%

sodium tosylate (657-84-1) + tert-butyl 2-(2-methoxyethoxymethyl)acrylate (133208-86-3) → C18H26O6S

Conditions	Yield
Stage #1: sodium tosylate; tert-butyl 2-(2-methoxyethoxymethyl)acrylate With iodine In ethyl acetate Stage #2: With triethylamine	97%

allylbenzene (300-57-2) + sodium tosylate (657-84-1) → (3-phenylpropyl)(p-tolyl)sulfane (38644-97-2)

Conditions	Yield
With sulfuric acid; triphenylphosphine In water at 50℃; for 10h;	97%

1-(2-chlorophenyl)ethanone (2142-68-9) + sodium tosylate (657-84-1) → 1-(2-chlorophenyl)-2-(p-tosyl)ethanone (710984-18-2)

Conditions	Yield
With iodine; triethylamine In methanol at 20℃; for 6h;	96%

Cinnamyl acetate (21040-45-9) + sodium tosylate (657-84-1) → trans-cinnamyl p-tolyl sulfone (16215-11-5)

Conditions	Yield
With palladium 10% on activated carbon; cetyltrimethylammonim bromide; triphenylphosphine In water at 70℃; for 3h; Tsuji-Trost Allylation; Micellar solution; Green chemistry;	96%

2,4,6-trimethylstyrene (769-25-5) + sodium tosylate (657-84-1) → p-tolyl(2,4,6-trimethylphenethyl)sulfane

Conditions	Yield
With sulfuric acid; triphenylphosphine In water at 50℃; for 10h;	96%

sodium tosylate (657-84-1) + β-naphthol (135-19-3) → 1-(4-methylphenylsulfenyl)naphthalen-2-ol (799764-32-2)

Conditions	Yield
With hydrogenchloride In water at 80℃; for 6h;	96%

sodium tosylate (657-84-1) + 1,3,5-trimethyl-benzene (108-67-8) → 1,3,5-trimethyl-2-(toluene-4-sulfonyl)-benzene (5184-64-5)

Conditions	Yield
With methanesulfonic acid; phosphorus pentoxide at 20℃; for 24h;	95%

(μ-pyrazine)decaamminediruthenium(II,III) pentachloride (94780-98-0) + sodium tosylate (657-84-1) → Creutz-Taube complex (87922-21-2)

Conditions	Yield
In water under Ar, a satd. aq. soln. of Na(tos) was added to a soln. of ((NH3)5Ru(N2C4H4)Ru(NH3)5)Cl5*5H2O in water; ppt. was filtered off, washed with ethanol and ether, dried in vac.; elem. anal.;	95%

2,6-dichlorostyrene (28469-92-3) + sodium tosylate (657-84-1) → (E)-1,3-dichloro-2-(2-tosylvinyl)benzene (1346705-02-9)

Conditions	Yield
With sodium periodate; acetic acid; potassium iodide In acetonitrile at 20℃; for 3h;	95%

1-hexadecyl-3-(6-hydroxyhexyl)imidazolium chloride (1354971-75-7) + sodium tosylate (657-84-1) → 1-hexadecyl-3-(6-hydroxyhexyl)imidazolium tosylate (1354971-77-9)

Conditions	Yield
In dichloromethane; water	95%

ethyl 2-benzoylacrylate (22415-01-6) + sodium tosylate (657-84-1) → 2-(4-methylbenzyl)-3-oxo-3-phenylpropionic acid ethyl ester

Conditions	Yield
With copper dichloride; palladium dichloride In 1,4-dioxane at 90℃; for 8h; Baylis-Hillman Reaction;	95%

C14H16O3 + sodium tosylate (657-84-1) → butyl 2-(4-methylbenzyl)-3-oxo-3-phenylpropanoate (1407163-01-2)

Conditions	Yield
With copper dichloride; palladium dichloride In 1,4-dioxane at 90℃; for 8h; Baylis-Hillman Reaction;	95%

sodium tosylate (657-84-1) + para-bromoacetophenone (99-90-1) → 1-(4-bromophenyl)-2-tosylethanone (31377-97-6)

Conditions	Yield
With iodine; triethylamine In methanol at 20℃; for 6h;	95%

sodium tosylate (657-84-1) + acetone (67-64-1) → 4-toluenesulfonylacetone (5366-49-4)

Conditions	Yield
With iodine; triethylamine at 20℃; for 6h;	95%

2-vinylpyridine (100-69-6) + sodium tosylate (657-84-1) → 4-methylphenyl 2-(2-pyridyl)ethyl sulfide (109845-78-5)

Conditions	Yield
With sulfuric acid; triphenylphosphine In water at 50℃; for 10h;	95%

sodium tosylate (657-84-1) → p-toluenesulfonyl chloride (98-59-9)

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; 18-crown-6 ether In acetone for 20h; Heating;	94%
Stage #1: sodium tosylate With potassium phosphate; bis(trichloromethyl) carbonate In dichloromethane at 0 - 5℃; for 0.0833333h; Stage #2: With triethylamine In dichloromethane at 20℃; for 0.5h;	93%
With trichlorophosphate In sulfolane; acetonitrile at 68 - 72℃; for 0.666667h;	87%

Upstream product

• 64-17-5 ethanol 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 5447-97-2 2-bromo-2-nitropropane 
• 14894-58-7 p-tolylsulfonylmethyl p-toluenesulfonate 
• 778-28-9 butyl para-toluenesulfonate 
• 85-19-8 (5-chloro-2-hydroxyphenyl)phenylmethanone 
• 80-41-1 2-chloroethyl tosylate 
• 57392-61-7 toluene-4-sulfonic acid 2,2,2-trichloro-ethyl ester 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 13652-13-6 toluene-4-sulfonic acid 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 67674-48-0 toluene-4-sulfonic acid 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester 
• 67-56-1 methanol 
• 18137-96-7 nitromethane anion 

Downstream Products

• 94957-41-2 phenyl(propenyl)iodonium tosylate 
• 778-28-9 butyl para-toluenesulfonate 
• 26788-89-6 phenylazo 4-methylphenyl sulfone 
• 141246-58-4 4-Iodo-5-(toluene-4-sulfonyl)-pentan-1-ol 
• 503544-97-6 N-[2-(3-indolyl)ethyl]-2-(4-methylphenylsulfonyl)acetamide 
• 104172-19-2 (NH₃)5RuNCSe⁽²⁺⁾*2C₇H₇SO₃^(1-)=[(NH₃)5RuNCSe](C₇H₇SO₃)2 
• 104155-35-3 (NH₃)5RuSeCN⁽²⁺⁾*2C₇H₇SO₃^(1-)=[(NH₃)5RuSeCN](C₇H₇SO₃)2 
• 1045822-63-6 1-{[(trifluoromethyl)thio]methyl}undecyl 4-methylbenzenesulfonate 
• 1045822-91-0 1-{1-[(trifluoromethyl)thio]ethylidene}butyl 4-methylbenzenesulfonate 
• 1045823-49-1 1-methyl-2-[(trifluoromethyl)thio]pent-1-en-1-yl 4-methylbenzenesulfonate 
• 1045822-93-2 1-{[(trifluoromethyl)thio]methylene}heptyl 4-methylbenzenesulfonate 
• 1045822-65-8 3-phenyl-1-{[(trifluoromethyl)thio]methyl}propyl 4-methylbenzenesulfonate 

Relevant articles and documents

Predicting the hydrolytic breakdown rates of organophosphorus chemical warfare agent simulants using association constants derived from hydrogen bonded complex formation events

Organophosphorus (OP) chemical warfare agents (CWAs) represent an ongoing global threat, through either purposeful environmental release or the need to dispose of historic stockpiles. This presents a need for the development of novel decontamination technologies. Due to the toxic nature and legal limitations placed on OP CWAs, the use of appropriate OP simulants that mimic the reactivity but not the toxicity of the agents themselves is vital to decontamination studies. Herein, we show that association constants derived from non-specific hydrogen bonded complexation events may be used as parameters within models to predict simulant reactivity. We also discuss the limitations that should be placed on such data.

Method for recycling byproduct p-toluene magnesium sulfonate to synthesize tenofovir

The invention relates to the technical field of medicine chemicals and in particular discloses a method for recycling a byproduct p-toluene magnesium sulfonate to synthesize tenofovir. According to the method, hydroxymethylphosphonic acid diethyl ester and paratoluensulfonyl chloride are adopted as raw materials, magnesium carbonate is adopted as an acid-binding agent, p-toluenesulfonyl oxymethyldiethyl phosphate is synthesized, tenofovir is synthesized from the p-toluenesulfonyl oxymethyl diethyl phosphate and R-9-(2-hydroxypropyl), and meanwhile, a byproduct p-toluene magnesium sulfonate isgenerated; and magnesium carbonate and sodium p-toluenesulfonate are generated through a reaction of the p-toluene magnesium sulfonate and sodium carbonate. According to the method, the byproduct p-toluene magnesium sulfonate is mainly recycled, process treatment difficulties are reduced, byproducts p-toluene magnesium sulfonate and magnesium chloride which are obtained after treatment are high in purity, export sales can be achieved, the magnesium carbonate can be applied to synthesis of the p-toluenesulfonyl oxymethyl diethyl phosphate, and the production cost can be reduced.

Profiling sulfonate ester stability: Identification of complementary protecting groups for sulfonates

(Figure presented) Sulfonation is prized for its ability to impart water-solubility to hydrophobic molecules such as dyes. This modification is usually performed as a final step, since sulfonated molecules are poorly soluble in most organic solvents, which complicates their synthesis and purification. This work compares the intrinsic lability of different sulfonate esters, identifying new sulfonate protecting groups and mild, selective cleavage conditions.