methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1336964-58-9
Molecular Formula:C₁₉H₁₁Br₂F₄NO₂
Molecular Weight:521.103
Hs Code.:

Synonyms:methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Chemical Property:

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Technology Process of methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 7 articles about methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1336964-56-7
methyl 7-bromo-8-fluoro-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1336964-58-9
methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 18h; Reflux;

Reference yield:

3-bromo-2-fluorobenzoic acid: 161957-56-8
3-bromo-2-fluorobenzoic acid

: 1336964-58-9
methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene; tert-butyl alcohol / 4 h / Reflux

1.2: 18 h / 20 °C

2.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / 1,4-dioxane; water / 1 h / 50 - 80 °C

3.1: sulfuric acid / 1.5 h / 50 - 80 °C

4.1: potassium hydroxide / ethanol; water

4.2: 1.5 h / Reflux

4.3: pH 2

5.1: thionyl chloride / 3 h / Reflux

5.2: 20 °C

6.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium sulfate; triethylamine; potassium hydroxide; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; ethanol; water; toluene; tert-butyl alcohol;

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 1336964-58-9
methyl 7-bromo-3-(bromomethyl)-8-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 2 h / -78 °C

1.3: pH 2

2.1: triethylamine; diphenyl phosphoryl azide / toluene; tert-butyl alcohol / 4 h / Reflux

2.2: 18 h / 20 °C

3.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / 1,4-dioxane; water / 1 h / 50 - 80 °C

4.1: sulfuric acid / 1.5 h / 50 - 80 °C

5.1: potassium hydroxide / ethanol; water

5.2: 1.5 h / Reflux

5.3: pH 2

6.1: thionyl chloride / 3 h / Reflux

6.2: 20 °C

7.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; water; toluene; tert-butyl alcohol;