(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

Base Information

Chemical Name:(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate
CAS No.:1365533-62-5
Molecular Formula:C₁₉H₁₉BrN₂O₄S
Molecular Weight:451.341
Hs Code.:

Synonyms:(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

Suppliers and Price of (S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

Chemical Property:

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Technology Process of (S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

There total 1 articles about (S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 1365533-62-5
(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 1 h / 0 °C

With pyridinium hydrobromide perbromide; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield: 87.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1365533-62-5
(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

: 1365533-63-6
(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 1365533-62-5
(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

: C₂₃H₂₇BrN₂O₅S

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 2 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 16 h / 0 - 20 °C

2.2: 20 °C

With dmap; sodium tetrahydroborate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2012.01.037