(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate
CAS No.:1365533-63-6
Molecular Formula:C₂₄H₂₇BrN₂O₆S
Molecular Weight:551.458
Hs Code.:

Synonyms:(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

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Technology Process of (S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

There total 4 articles about (S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1365533-62-5
(S)-methyl 3-(2-bromo-1H-indol-3-yl)-2-(p-toluenesulfonamido)propanoate

: 1365533-63-6
(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1365533-63-6
(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 1 h / 0 °C

3: dmap / dichloromethane / 2 h / 20 °C

With dmap; pyridinium hydrobromide perbromide; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 1365533-63-6
(S)-tert-butyl 2-bromo-3-(3-methoxy-2-(p-toluenesulfonamido)-3-oxopropyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 1 h / 0 °C

3: dmap / dichloromethane / 2 h / 20 °C

With dmap; pyridinium hydrobromide perbromide; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.tetlet.2012.01.037