1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

• Chemical Name: 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS No.: 114702-44-2
• Molecular Formula: C₁₄H₁₁F₃N₂O₃
• Molecular Weight: 312.248
• Mol file: 114702-44-2.mol

Synonyms:1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property of 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 2 articles about 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + 1,3-dimethylbarbituric acid (769-42-6) → 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (114702-44-2)

Guidance literature:

In ethanol; for 1h; Heating;

Reference yield:

1,3-dimethyl-5-(4-trifluoromethylbenzyl)lbarbituric acid + 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium → 1-hydroxy-2,2,6,6-tetramethyl-4-acetamidopiperidine + 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (114702-44-2)

Guidance literature:

1,3-dimethyl-5-(4-trifluoromethylbenzyl)lbarbituric acid; With potassium hydride; In acetonitrile; at 20 ℃; for 0.333333h; Inert atmosphere; Glovebox;

4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium; In acetonitrile; at 24.84 ℃; Thermodynamic data; Inert atmosphere; Glovebox;

DOI:10.1021/jo4010926

Reference yield: 99.0%

3-isothiocyanato-1-methylindolin-2-one (1287715-28-9) + 1,3-dimethyl-5-(4-(trifluoromethyl)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (114702-44-2) → C24H19F3N4O4S

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.0333333h; diastereoselective reaction;

DOI:10.1021/acs.joc.5b01810

upstream raw materials:

4-Trifluoromethylbenzaldehyde

1,3-dimethylbarbituric acid