N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

Base Information

Chemical Name:N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide
CAS No.:1428552-76-4
Molecular Formula:C₂₈H₃₄BrF₃N₆O₃
Molecular Weight:639.516
Hs Code.:

Synonyms:N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

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Chemical Property of N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

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Technology Process of N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

There total 6 articles about N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428552-75-3
tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

: 1428552-76-4
N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.25h;

Reference yield:

: 1428552-72-0
tert-butyl 4-((6-((4-hydroxybenzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoate

: 1428552-76-4
N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 16 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 0.17 h

3: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.25 h

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetone;

Reference yield:

: 1428552-70-8
4,6-dichloro-2-(2,2,2-trifluoroethoxy)pyrimidine

: 1428552-76-4
N-(3-amino-2,2-dimethylpropyl)-4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / Reflux

3: potassium carbonate / acetone / 16 h / Reflux

4: hydrogenchloride / 1,4-dioxane / 0.17 h

5: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0.25 h

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;