tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

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Chemical Name:tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate
CAS No.:1428552-75-3
Molecular Formula:C₃₃H₄₂BrF₃N₆O₅
Molecular Weight:739.633
Hs Code.:

Synonyms:tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

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Chemical Property of tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

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Technology Process of tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

There total 6 articles about tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1428552-74-2
4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoic acid

: 292606-35-0
N-tert-butyloxycarbonyl-2,2-dimethyl-1,3-propanediamine

: 1428552-75-3
tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1428552-72-0
tert-butyl 4-((6-((4-hydroxybenzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoate

: 1428552-75-3
tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 16 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 0.17 h

3: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; acetone;

Reference yield:

: 1428552-70-8
4,6-dichloro-2-(2,2,2-trifluoroethoxy)pyrimidine

: 1428552-75-3
tert-butyl (3-(4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / Reflux

3: potassium carbonate / acetone / 16 h / Reflux

4: hydrogenchloride / 1,4-dioxane / 0.17 h

5: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;