4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

Base Information

• Chemical Name: 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)
• CAS No.: 1334149-63-1
• Molecular Formula: C₂₅H₃₄Cl₄N₄O₈P₂
• Molecular Weight: 722.326
• Mol file: 1334149-63-1.mol

Synonyms:4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

Chemical Property of 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

There total 4 articles about 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-62-0) → 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-63-1)

Guidance literature:

With sodium hypochlorite solution; N-benzyl-N,N,N-triethylammonium chloride; In methanol; tetrachloromethane; for 4h; Inert atmosphere;

DOI:10.1021/jm200521a

Reference yield:

N-methyl-N-(4-chloro-n-butyl)amine hydrochloride → 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: sodium hypochlorite solution; N-benzyl-N,N,N-triethylammonium chloride / methanol; tetrachloromethane / 4 h / Inert atmosphere

With dmap; sodium hypochlorite solution; N-benzyl-N,N,N-triethylammonium chloride; N-ethyl-N,N-diisopropylamine; In methanol; tetrachloromethane; dichloromethane;

DOI:10.1021/jm200521a

Reference yield:

4-nitrobenzyl chloride (619-73-8) + C11H24Cl4N2O2P2 (1346258-34-1) → 4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: sodium hypochlorite; N-benzyl-N,N,N-triethylammonium chloride / methanol; tetrachloromethane / 4 h

With sodium hypochlorite; N-benzyl-N,N,N-triethylammonium chloride; N-ethyl-N,N-diisopropylamine; dmap; In methanol; tetrachloromethane; dichloromethane;

upstream raw materials:

C₁₁H₂₄Cl₄N₂O₂P₂

4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

4-nitrobenzyl chloride