4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

Base Information

• Chemical Name: 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)
• CAS No.: 1334149-62-0
• Molecular Formula: C₂₅H₃₆Cl₂N₄O₈P₂
• Molecular Weight: 653.436
• Mol file: 1334149-62-0.mol

Synonyms:4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

Chemical Property of 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)

There total 3 articles about 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

benzyl nitrate (15285-42-4) + C11H24Cl4N2O2P2 (1346258-34-1) → 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-62-0)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm200521a

Reference yield:

4-nitrobenzyl chloride (619-73-8) + C11H24Cl4N2O2P2 (1346258-34-1) → 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-62-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

N-methyl-N-(4-chloro-n-butyl)amine hydrochloride → 4-nitrobenzyl methylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate) (1334149-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm200521a

upstream raw materials:

4-nitrobenzyl chloride

C₁₁H₂₄Cl₄N₂O₂P₂

benzyl nitrate

Downstream raw materials:

4-nitrobenzyl dichloromethylenebis(N-(4-chlorobutyl)-N-methylphosphonamidate)