methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Base Information

Chemical Name:methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate
CAS No.:1356113-91-1
Molecular Formula:C₂₅H₂₃FN₂O₆S
Molecular Weight:498.532
Hs Code.:

Synonyms:methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

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Chemical Property of methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

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Technology Process of methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

There total 10 articles about methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503-29-7
azetidine

: 1356113-97-7
methyl 7-{N-[4-fluoro-2-((Z)-3-hydroxyprop-1-enyl)-benzenesulfonyl]-N-(methoxycarbonyl)amino}-4H-furo[2,3-c]chromene-6-carboxylate

: 1356113-91-1
methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: methyl 7-{N-[4-fluoro-2-((Z)-3-hydroxyprop-1-enyl)-benzenesulfonyl]-N-(methoxycarbonyl)amino}-4H-furo[2,3-c]chromene-6-carboxylate; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

azetidine; In dichloromethane; toluene; at 20 ℃; for 1h;

Reference yield:

: 681247-11-0
methyl 6-amino-3-bromo-2-hydroxybenzoate

: 1356113-91-1
methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 20 °C

8.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 70 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 0.25 h / 20 °C

9.2: 1 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; carbon tetrabromide; water; sodium hydride; caesium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;

Reference yield:

: 1055881-23-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-2-carbaldehyde

: 1356113-91-1
methyl 7-{2-[(Z)-3-(azetidin-1-yl)prop-1-enyl]-4-fluorobenzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 20 °C

8.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 70 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 0.25 h / 20 °C

9.2: 1 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; carbon tetrabromide; water; sodium hydride; caesium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;