Technology Process of methyl 7-{N-[4-fluoro-2-((Z)-3-hydroxyprop-1-enyl)-benzenesulfonyl]-N-(methoxycarbonyl)amino}-4H-furo[2,3-c]chromene-6-carboxylate
There total 8 articles about methyl 7-{N-[4-fluoro-2-((Z)-3-hydroxyprop-1-enyl)-benzenesulfonyl]-N-(methoxycarbonyl)amino}-4H-furo[2,3-c]chromene-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 1 h
2.2: 2 h
3.1: ethanol; sodium tetrahydroborate / 0.25 h
4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C
5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C
5.2: 1 h
6.1: hydrogenchloride / 1,4-dioxane / 1.5 h
6.2: 18 h
7.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 20 °C
8.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 0.5 h / 70 °C / Inert atmosphere
With
hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; carbon tetrabromide; water; sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 1 h
2.2: 2 h
3.1: ethanol; sodium tetrahydroborate / 0.25 h
4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C
5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C
5.2: 1 h
6.1: hydrogenchloride / 1,4-dioxane / 1.5 h
6.2: 18 h
7.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 20 °C
8.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 0.5 h / 70 °C / Inert atmosphere
With
hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; carbon tetrabromide; water; sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 20 °C
2: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 0.5 h / 70 °C / Inert atmosphere
With
sodium hydride; tri tert-butylphosphoniumtetrafluoroborate;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; 1,4-dioxane; water; mineral oil;
