4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

Base Information

• Chemical Name: 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde
• CAS No.: 888709-52-2
• Molecular Formula: C₂₃H₂₀N₆O
• Molecular Weight: 396.451

Synonyms:4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

Chemical Property of 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

Chemical Property:

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Technology Process of 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

There total 6 articles about 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

[4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-methanol (310443-74-4) → 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde (888709-52-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane;

DOI:10.1016/j.bmcl.2005.07.027

Reference yield:

ethyl 4-chloro-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (310442-94-5) → 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde (888709-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / acetonitrile

2: 91 percent / DIBAL-H / tetrahydrofuran / 23 °C

3: 87 percent / MnO₂ / CH₂Cl₂

With manganese(IV) oxide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2005.07.027

Reference yield:

5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester (310436-60-3) → 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde (888709-52-2)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃ / 100 °C

2: Et₃N / acetonitrile

3: 91 percent / DIBAL-H / tetrahydrofuran / 23 °C

4: 87 percent / MnO₂ / CH₂Cl₂

With manganese(IV) oxide; diisobutylaluminium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2005.07.027

upstream raw materials:

[4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-methanol

ethyl 4-chloro-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester

1-amino-3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

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