Ethyl 5-ethyl-4-hydroxypy...

Base Information

• Chemical Name: Ethyl 5-ethyl-4-hydroxypy...
• CAS No.: 310436-60-3
• Molecular Formula: C₁₁H₁₃N₃O₃
• Molecular Weight: 235.243
• Hs Code.: 2933990090
• Mol file: 310436-60-3.mol

Synonyms:Ethyl 5-ethyl-4-hydroxypy...;Ethyl 5-ethyl-4-hydroxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate;ethyl 5-ethyl-4-hydroxypyrrolo[2,1-f][1,2,4]triazine-6-carboxylate;Ethyl 5-ethyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Chemical Property of Ethyl 5-ethyl-4-hydroxypy...

Chemical Property:

• PSA: 76.72000
• LogP: 1.17400

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 5-ethyl-4-hydroxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-ethyl-4-hydroxypy...

There total 4 articles about Ethyl 5-ethyl-4-hydroxypy... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-amino-3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (869066-98-8) + formamide (77287-34-4,77287-35-5,60100-09-6) → 5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester (310436-60-3)

Guidance literature:

at 165 ℃;

DOI:10.1016/j.bmcl.2005.07.027

Reference yield:

Ethyl isocyanoacetate (2999-46-4) → 5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester (310436-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: DBU / tetrahydrofuran / 50 °C

2: O-(diphenylphosphinyl)-hydroxylamine; NaH / dimethylformamide

3: 87 percent / 165 °C

With O-(diphenylphosphinyl)hydroxylamine; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.07.027

Reference yield:

3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (52921-22-9) → 5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester (310436-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(diphenylphosphinyl)-hydroxylamine; NaH / dimethylformamide

2: 87 percent / 165 °C

With O-(diphenylphosphinyl)hydroxylamine; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.07.027

upstream raw materials:

1-amino-3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

formamide

Ethyl isocyanoacetate

3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

Downstream raw materials:

ethyl 4-chloro-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

[4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-methanol

5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid

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